发明申请
US20150246034A1 PHARMACEUTICAL COMPOSITIONS FOR EXTENDED RELEASE OF OXYCODONE AND ACETAMINOPHEN RESULTING IN A QUICK ONSET AND PROLONGED PERIOD OF ANALGESIA
有权
药物组合物用于延长释放氧气和乙酰氨基酚在快速上瘾和延长期间的药代动力学
- 专利标题： PHARMACEUTICAL COMPOSITIONS FOR EXTENDED RELEASE OF OXYCODONE AND ACETAMINOPHEN RESULTING IN A QUICK ONSET AND PROLONGED PERIOD OF ANALGESIA
- 专利标题（中）： 药物组合物用于延长释放氧气和乙酰氨基酚在快速上瘾和延长期间的药代动力学
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申请号： US14659819申请日： 2015-03-17
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公开(公告)号： US20150246034A1公开(公告)日： 2015-09-03
- 发明人: Krishna Devarakonda , Michael J. Giuliani , Vishal K. Gupta , Ralph A. Heasley , Susan Shelby
- 申请人： MALLINCKRODT LLC
- 主分类号： A61K31/485
- IPC分类号： A61K31/485 ; A61K9/20 ; A61K31/167
摘要：
The present disclosure provides extended release pharmaceutical compositions comprising oxycodone and acetaminophen that produce a quick initial onset of analgesia, yet, maintain analgesia for about 12 hours after administration of the composition to a subject in need thereof. The pharmaceutical compositions disclosed herein also reduce the levels of acetaminophen in a subject's blood near the end of the dosing interval because the acetaminophen released by the pharmaceutical composition is being eliminated by a subject's body faster than it is being absorbed.
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