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公开(公告)号：US09629837B2
公开(公告)日：2017-04-25
申请号：US14659819
申请日：2015-03-17
申请人： MALLINCKRODT LLC
IPC分类号： A61K31/485 , A61K9/24 , A61K31/167 , A61K9/20 , A61K9/00 , A61K47/10
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/2013 , A61K9/2031 , A61K9/2054 , A61K9/2086 , A61K9/209 , A61K31/167 , A61K47/10 , A61K2300/00
摘要： The present disclosure provides extended release pharmaceutical compositions comprising oxycodone and acetaminophen that produce a quick initial onset of analgesia, yet, maintain analgesia for about 12 hours after administration of the composition to a subject in need thereof. The pharmaceutical compositions disclosed herein also reduce the levels of acetaminophen in a subject's blood near the end of the dosing interval because the acetaminophen released by the pharmaceutical composition is being eliminated by a subject's body faster than it is being absorbed.
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公开(公告)号：US20170182033A1
公开(公告)日：2017-06-29
申请号：US15457674
申请日：2017-03-13
申请人： MALLINCKRODT LLC
IPC分类号： A61K31/485 , A61K31/167
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/2013 , A61K9/2031 , A61K9/2054 , A61K9/2086 , A61K9/209 , A61K31/167 , A61K47/10 , A61K2300/00
摘要： The present disclosure provides extended release pharmaceutical compositions comprising oxycodone and acetaminophen that produce a quick initial onset of analgesia, yet, maintain analgesia for about 12 hours after administration of the composition to a subject in need thereof. The pharmaceutical compositions disclosed herein also reduce the levels of acetaminophen in a subject's blood near the end of the dosing interval because the acetaminophen released by the pharmaceutical composition is being eliminated by a subject's body faster than it is being absorbed.
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3.发明申请PHARMACEUTICAL COMPOSITIONS FOR EXTENDED RELEASE OF OXYCODONE AND ACETAMINOPHEN RESULTING IN A QUICK ONSET AND PROLONGED PERIOD OF ANALGESIA 有权药物组合物用于延长释放氧气和乙酰氨基酚在快速上瘾和延长期间的药代动力学公开(公告)号：US20150246034A1
公开(公告)日：2015-09-03
申请号：US14659819
申请日：2015-03-17
申请人： MALLINCKRODT LLC
IPC分类号： A61K31/485 , A61K9/20 , A61K31/167
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/2013 , A61K9/2031 , A61K9/2054 , A61K9/2086 , A61K9/209 , A61K31/167 , A61K47/10 , A61K2300/00
摘要： The present disclosure provides extended release pharmaceutical compositions comprising oxycodone and acetaminophen that produce a quick initial onset of analgesia, yet, maintain analgesia for about 12 hours after administration of the composition to a subject in need thereof. The pharmaceutical compositions disclosed herein also reduce the levels of acetaminophen in a subject's blood near the end of the dosing interval because the acetaminophen released by the pharmaceutical composition is being eliminated by a subject's body faster than it is being absorbed.
摘要翻译： 本公开内容提供了包含羟考酮和对乙酰氨基酚的延长释放药物组合物，其产生快速起始镇痛，然而，在将组合物施用于有需要的受试者后，维持止痛约12小时。 本文公开的药物组合物还降低了在给药间隔结束时受试者血液中的对乙酰氨基酚的水平，因为药物组合物释放的对乙酰氨基酚被受试者的身体比被吸收更快地消除。
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4.发明授权Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia 有权防篡改组合物包含氢可酮和对乙酰氨基酚，用于快速发作和延长的止痛持续时间公开(公告)号：US09539328B2
公开(公告)日：2017-01-10
申请号：US14479129
申请日：2014-09-05
申请人： MALLINCKRODT LLC
IPC分类号： A61K9/20 , A61K47/10 , A61K51/12 , A61K9/24 , A61K31/167 , A61K31/485
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/2031 , A61K9/2086 , A61K9/209 , A61K31/167 , A61K47/10 , A61K51/1258
摘要： The present disclosure provides an extended release pharmaceutical composition comprising hydrocodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.
摘要翻译： 本公开内容提供了包含氢可酮和对乙酰氨基酚的延长释放药物组合物，其在给药间隔结束附近提供快速起搏镇痛和降低的对乙酰氨基酚水平。 还提供了降低用含对乙酰氨基酚组合物治疗的受试者中对乙酰氨基酚诱发的肝损伤风险的方法，以及用于治疗有需要的受试者的疼痛的方法。
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