Invention Application
US20150299183A1 AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES
有权
用作IL-12，IL-23和/或IFN ALPHA反应的调节剂的酰胺取代的杂环化合物
- Patent Title: AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES
- Patent Title (中): 用作IL-12，IL-23和/或IFN ALPHA反应的调节剂的酰胺取代的杂环化合物
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Application No.: US14441183Application Date: 2013-11-07
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Publication No.: US20150299183A1Publication Date: 2015-10-22
- Inventor: Ryan M. Moslin , David S. Weinstein , Stephen T. Wrobleski , John S, Tokarski , Amit Kumar , Douglas G. Batt , Shuqun Lin , Chunjian Liu , Steven H. Spergel , Yanlei Zhang
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- International Application: PCT/US2013/068846 WO 20131107
- Main IPC: C07D417/14
- IPC: C07D417/14 ; C07D403/12 ; C07D401/14 ; C07D401/12
Abstract:
Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
Public/Granted literature
- US09505748B2 Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFNα responses Public/Granted day:2016-11-29
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