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1.发明申请公开(公告)号：US20170209426A1
公开(公告)日：2017-07-27
申请号：US15480787
申请日：2017-04-06
发明人： Ryan M. Moslin , David S. Weinstein , Stephen T. Wrobleski , Yanlei Zhang , John S. Tokarski , Michael E. Mertzman , Chunjian Liu
IPC分类号： A61K31/455 , A61K31/506
CPC分类号： A61K31/455 , A61K31/44 , A61K31/444 , A61K31/506 , C07B59/002 , C07B2200/05 , C07D213/56 , C07D213/82 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Compounds having the following formula I: or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα by acting on Tyk-2 to cause signal transduction inhibition.
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公开(公告)号：US20230150979A1
公开(公告)日：2023-05-18
申请号：US17425336
申请日：2020-01-28
发明人： Trevor C. Sherwood , Michael G. Yang , John L. Gilmore , Yanlei Zhang , Zili Xiao , Qingjie Liu
IPC分类号： C07D403/12 , C07D413/12 , C07D237/24 , C07D213/82 , C07D413/14 , C07D401/14 , C07D401/12 , C07D405/14 , C07D417/12 , C07D417/14
CPC分类号： C07D403/12 , C07D413/12 , C07D237/24 , C07D213/82 , C07D413/14 , C07D401/14 , C07D401/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07B2200/05
摘要： Compounds having the following formula (I): (Formula (I)) or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition.
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公开(公告)号：US20220356180A1
公开(公告)日：2022-11-10
申请号：US17244938
申请日：2021-04-29
发明人： Ryan M. Moslin , David S. Weinstein , Stephen T. Wrobleski , John S. Tokarski , Amit Kumar , Douglas G. Batt , Shuqun Lin , Chunjian Liu , Steven H. Spergel , Yanlei Zhang , Qingjie Liu
IPC分类号： C07D417/14 , C07D403/12 , C07D401/14 , C07D413/14 , C07D401/12 , C07D237/24 , C07D403/14 , C07D413/12 , C07D417/12 , C07B59/00
摘要： Compounds having the following formula I. or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
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4.发明申请公开(公告)号：US20180325899A1
公开(公告)日：2018-11-15
申请号：US15776094
申请日：2016-11-17
发明人： David S. Weinstein , Ryan M. Moslin , Yanlei Zhang , Daniel S. Gardner , Joseph B. Santella , Charles M. Langevine , Sylwia Stachura
IPC分类号： A61K31/5025 , A61K31/53 , A61K31/5377 , A61P29/00 , A61P37/02
CPC分类号： A61K31/5025 , A61K31/53 , A61K31/5377 , A61P29/00 , A61P37/02 , C07D487/04
摘要： Compounds of formula I or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
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5.发明申请公开(公告)号：US20180265504A1
公开(公告)日：2018-09-20
申请号：US15979770
申请日：2018-05-15
发明人： Ryan M. Moslin , David S. Weinstein , Stephen T. Wrobleski , John S. Tokarski , Amit Kumar , Douglas G. Batt , Shuqun Lin , Chunjian Liu , Steven H. Spergel , Yanlei Zhang , Qingjie Liu
IPC分类号： C07D417/14 , C07B59/00 , C07D417/12 , C07D413/12 , C07D403/12 , C07D237/24 , C07D401/12 , C07D413/14 , C07D401/14 , C07D403/14
摘要： Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
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公开(公告)号：US10000480B2
公开(公告)日：2018-06-19
申请号：US15289437
申请日：2016-10-10
发明人： Ryan M. Moslin , David S. Weinstein , Stephen T. Wrobleski , John S. Tokarski , Amit Kumar , Douglas G. Batt , Shuqun Lin , Chunjian Liu , Steven H. Spergel , Yanlei Zhang , Qingjie Liu
IPC分类号： C07D417/14 , C07D403/12 , C07D401/14 , C07D413/14 , C07D401/12 , C07D237/24 , C07D403/14 , C07D413/12 , C07D417/12 , C07B59/00
摘要： Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
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7.发明授权Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses 有权可用作IL-12，IL-23和/或IFNα应答调节剂的烷基酰胺取代的吡啶基化合物公开(公告)号：US09315494B2
公开(公告)日：2016-04-19
申请号：US14441193
申请日：2013-11-07
发明人： Ryan M. Moslin , Shuqun Lin , David S. Weinstein , Stephen T. Wrobleski , Yanlei Zhang , John S. Tokarski , Michael E. Mertzman
IPC分类号： C07D401/12 , A61K31/444 , C07D413/14 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Compounds having the following formula (I): or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
摘要翻译： 具有下式（I）的化合物或其立体异构体或药学上可接受的盐，其中R 1，R 2，R 3，R 4和R 5如本文所定义，可用于调节IL-12，IL-23和/ 或IFNα，通过作用于Tyk-2以引起信号转导抑制。
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8.发明申请ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES 有权用作IL-12，IL-23和/或IFN ALPHA反应的调节剂的烷基酰胺取代的吡啶化合物公开(公告)号：US20150307483A1
公开(公告)日：2015-10-29
申请号：US14441193
申请日：2013-11-07
发明人： Ryan M. Moslin , Shuqun Lin , David S. Weinstein , Stephen T. Wrobleski , Yanlei Zhang , John S. Tokarski , Michael E. Mertzman
IPC分类号： C07D413/14 , C07D401/14 , C07D401/12
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Compounds having the following formula (I): or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
摘要翻译： 具有下式（I）的化合物或其立体异构体或药学上可接受的盐，其中R 1，R 2，R 3，R 4和R 5如本文所定义，可用于调节IL-12，IL-23和/ 或IFNα，通过作用于Tyk-2以引起信号转导抑制。
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公开(公告)号：US20210371404A1
公开(公告)日：2021-12-02
申请号：US17400100
申请日：2021-08-11
发明人： Yanlei Zhang , Michael A. Galella
IPC分类号： C07D403/12 , C07C211/09 , C07D237/24 , C07D249/08
摘要： Disclosed is crystalline Form A of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl) amino)-N-(methyl-d3)pyridazine-3-carboxamide. Form A is a neat crystalline form. Characterization data for Form A are disclosed.
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10.发明授权公开(公告)号：US10479793B2
公开(公告)日：2019-11-19
申请号：US15776094
申请日：2016-11-17
发明人： David S. Weinstein , Ryan M. Moslin , Yanlei Zhang , Daniel S. Gardner , Joseph B. Santella , Charles M. Langevine , Sylwia Stachura
IPC分类号： C07D487/04 , A61P37/02 , A61P29/00 , A61K31/5025 , A61K31/53 , A61K31/5377
摘要： Compounds of formula I or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
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