发明申请
US20150299301A1 POLYPEPTIDES AND POLYPEPTIDE CONSTRUCTS COMPRISING SINGLE DOMAIN ANTIBODIES DIRECTED AGAINST VON WILLEBRAND FACTOR
审中-公开
包含针对VON WILLEBRAND因子的单一抗体的多肽和多肽构建体
- 专利标题： POLYPEPTIDES AND POLYPEPTIDE CONSTRUCTS COMPRISING SINGLE DOMAIN ANTIBODIES DIRECTED AGAINST VON WILLEBRAND FACTOR
- 专利标题（中）： 包含针对VON WILLEBRAND因子的单一抗体的多肽和多肽构建体
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申请号： US14669025申请日： 2015-03-26
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公开(公告)号： US20150299301A1公开(公告)日： 2015-10-22
- 发明人: Karen Silence
- 申请人： Ablynx N.V.
- 申请人地址： BE Zwijnaarde
- 专利权人： Ablynx N.V.
- 当前专利权人： Ablynx N.V.
- 当前专利权人地址： BE Zwijnaarde
- 优先权： EP03447005.4 20030110
- 主分类号： C07K16/18
- IPC分类号： C07K16/18 ; G01N33/68 ; A61K45/06 ; A61L29/16 ; A61L31/10 ; A61L31/16 ; A61K39/395 ; A61L29/08
摘要：
The present invention relates to polypeptides comprising at least one single domain antibody directed against vWF, vWF A1 domain, A1 domain of activated vWF, vWF A3 domain, gpIb and/or collagen, homologues of said polypeptides, and/or functional portions of said polypeptides, for the treatment for conditions which require a modulation of platelet-mediated aggregation and which overcomes the problems of the prior art. A further aspect of the invention is methods of production of said polypeptides, methods to coat devices with such polypeptides used in medical procedures (e.g. PCTA, stenting), methods and kits for screening for agents that modulate platelet-mediated aggregation and kits for the diagnosis of diseases related to platelet-mediated aggregation.
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