A system for frequency-isolated self-interference cancellation includes a transmit coupler, that samples an RF transmit signal to create a sampled RF transmit signal having a first RF carrier frequency, an RF self-interference canceller that transforms the sampled RF transmit signal to an RF self-interference cancellation signal, a receive coupler, that combines the RF self-interference cancellation signal with an RF receive signal to form a reduced-interference receive signal, and a frequency shifter.