Invention Application
US20150336920A1 NOVEL COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF VIRAL DISEASES CONTAINING SAME AS ACTIVE INGREDIENT
有权
新型化合物,药学上可接受的盐或光学异构体,其制备方法以及用于预防或治疗含有作为活性成分的病毒性疾病的药物组合物
- Patent Title: NOVEL COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF VIRAL DISEASES CONTAINING SAME AS ACTIVE INGREDIENT
- Patent Title (中): 新型化合物,药学上可接受的盐或光学异构体,其制备方法以及用于预防或治疗含有作为活性成分的病毒性疾病的药物组合物
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Application No.: US14651656Application Date: 2013-12-16
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Publication No.: US20150336920A1Publication Date: 2015-11-26
- Inventor: Young Sik JUNG , Soo Bong HAN , Chong-Kyo LEE , Hae Soo KIM , Jin Soo SHIN , Neyts JOHAN , Jan Thibaut HENDRIK , Yashwardhan Radhamohan MALPANI
- Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , KATHOLIEKE UNIVERSITEIT LEUVEN K.U.LEUVEN R & D
- Priority: KR10-2012-0146081 20121214; KR10-2013-0156409 20131216
- International Application: PCT/KR2013/011668 WO 20131216
- Main IPC: C07D307/93
- IPC: C07D307/93 ; C07D417/12 ; C07D407/12 ; C07D405/12 ; C07D409/12

Abstract:
The present invention relates to a novel compound, to a pharmaceutically acceptable salt or optical isomer thereof, to a method for preparing same, and to a pharmaceutical composition for the prevention or treatment of viral diseases containing same as an active ingredient. The novel compound according to the present invention not only has low cytotoxicity but also has excellent antiviral activity against picornavirus such as coxsackievirus, enterovirus, echovirus, poliovirus and rhinovirus, and thus can be effectively used as a pharmaceutical composition for the prevention or treatment of viral diseases such as infantile paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myitis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinus infection, or otitis media.
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