Invention Application
US20150336925A1 SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS
审中-公开
取代苄基呋喃，苯并噻唑和吲哚酚一1抑制剂
- Patent Title: SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS
- Patent Title (中): 取代苄基呋喃，苯并噻唑和吲哚酚一1抑制剂
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Application No.: US14429799Application Date: 2013-09-20
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Publication No.: US20150336925A1Publication Date: 2015-11-26
- Inventor: Taekyu Lee , Nicholas F. Pelz , Johannes Belmar , Zhiguo Bian , Edward T. Olejniczak , Stephen W. Fesik , Brian A. Chauder
- Applicant: VANDERBILT UNIVERSITY
- Applicant Address: US TN Nashville
- Assignee: VANDERBILT UNIVERSITY
- Current Assignee: VANDERBILT UNIVERSITY
- Current Assignee Address: US TN Nashville
- International Application: PCT/US13/60881 WO 20130920
- Main IPC: C07D333/70
- IPC: C07D333/70 ; C07D307/85 ; C07D401/12 ; C07D405/10 ; C07D413/10 ; C07D401/10 ; C07D401/14 ; C07D405/12 ; A61K31/381 ; A61K31/343 ; A61K31/404 ; A61K31/4709 ; A61K31/422 ; A61K31/4439 ; A61K31/4155 ; A61K31/496 ; A61K31/5377 ; A61K45/06 ; C07D209/42
Abstract:
The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
Public/Granted literature
- US10093640B2 Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors Public/Granted day:2018-10-09
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