Invention Application
US20150366872A1 CRYSTALLINE FORMS OF (2R,5S,13AR)-8-HYDROXY-7,9-DIOXO-N-(2,4,6-TRIFLUOROBENZYL)-2,3,4,5,7,9,13,13A-OCTAHYDRO-2,5-METHANOPYRIDO[1',2':4,5]PYRAZINO[2,1-B][1,3]OXAZEPINE-10-CARBOXAMIDE
有权
（2R，5S，13AR）-8-羟基-7,9-二氧代-N-（2,4,6-三氟硼酸）-2,3,4,5,7,9,13,13a-八氢噻吩的结晶形式 -2,5-甲基吡咯并[1'，2'：4,5]吡咯并[2,1-B] [1,3]氧杂氮杂-10-羧酰胺
![CRYSTALLINE FORMS OF (2R,5S,13AR)-8-HYDROXY-7,9-DIOXO-N-(2,4,6-TRIFLUOROBENZYL)-2,3,4,5,7,9,13,13A-OCTAHYDRO-2,5-METHANOPYRIDO[1',2':4,5]PYRAZINO[2,1-B][1,3]OXAZEPINE-10-CARBOXAMIDE](/docs/US/2015-12-24/US20150366872A1/abs.jpg.600x600.jpg)
- Patent Title: CRYSTALLINE FORMS OF (2R,5S,13AR)-8-HYDROXY-7,9-DIOXO-N-(2,4,6-TRIFLUOROBENZYL)-2,3,4,5,7,9,13,13A-OCTAHYDRO-2,5-METHANOPYRIDO[1',2':4,5]PYRAZINO[2,1-B][1,3]OXAZEPINE-10-CARBOXAMIDE
- Patent Title (中): （2R，5S，13AR）-8-羟基-7,9-二氧代-N-（2,4,6-三氟硼酸）-2,3,4,5,7,9,13,13a-八氢噻吩的结晶形式 -2,5-甲基吡咯并[1'，2'：4,5]吡咯并[2,1-B] [1,3]氧杂氮杂-10-羧酰胺
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Application No.: US14745121Application Date: 2015-06-19
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Publication No.: US20150366872A1Publication Date: 2015-12-24
- Inventor: Ernest A. Carra , Irene Chen , Katie Ann Keaton , Vahid Zia
- Applicant: Gilead Sciences, Inc.
- Main IPC: A61K31/5365
- IPC: A61K31/5365 ; A61K45/06 ; A61K9/20 ; C07D498/18
![CRYSTALLINE FORMS OF (2R,5S,13AR)-8-HYDROXY-7,9-DIOXO-N-(2,4,6-TRIFLUOROBENZYL)-2,3,4,5,7,9,13,13A-OCTAHYDRO-2,5-METHANOPYRIDO[1',2':4,5]PYRAZINO[2,1-B][1,3]OXAZEPINE-10-CARBOXAMIDE](/abs-image/US/2015/12/24/US20150366872A1/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to crystalline forms and co-crystals of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide, the pharmaceutical formulations, and the therapeutic uses thereof. The present invention also relates to novel crystalline forms of sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.
Public/Granted literature
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