发明申请
- 专利标题: Amyloid beta1-6 Antigen Arrays
- 专利标题(中): 淀粉样β1-6抗原阵列
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申请号: US14788896申请日: 2015-07-01
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公开(公告)号: US20150374807A1公开(公告)日: 2015-12-31
- 发明人: Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Martin Lueoend , Matthias Staufenbiel , Peter Frey
- 申请人: Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Martin Lueoend , Matthias Staufenbiel , Peter Frey
- 申请人地址: CH Basel
- 专利权人: Novartis AG
- 当前专利权人: Novartis AG
- 当前专利权人地址: CH Basel
- 主分类号: A61K39/00
- IPC分类号: A61K39/00
摘要:
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune, responses within the indicated context.