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公开(公告)号:US20150374807A1
公开(公告)日:2015-12-31
申请号:US14788896
申请日:2015-07-01
申请人: Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Martin Lueoend , Matthias Staufenbiel , Peter Frey
发明人: Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Martin Lueoend , Matthias Staufenbiel , Peter Frey
IPC分类号: A61K39/00
CPC分类号: A61K39/0007 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64
摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune, responses within the indicated context.
摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供了包含有序和重复的抗原或抗原决定簇,特别是Aβ肽-VLP组合物的组合物。 更具体地,本发明提供了包含病毒样颗粒和与其结合的至少一个Aβ1-6肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物,并有效诱导免疫应答,特别是抗体应答。 此外,本发明的组合物特别可用于在指定的上下文中有效诱导自身特异性免疫,应答。
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公开(公告)号:US07279165B2
公开(公告)日:2007-10-09
申请号:US10622087
申请日:2003-07-18
申请人: Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Lūönd , Matthias Staufenbiel , Peter Frey
发明人: Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Lūönd , Matthias Staufenbiel , Peter Frey
IPC分类号: A61K39/385 , C07K17/06
CPC分类号: A61K39/0007 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64
摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇,特别是Abeta1-6肽-VLP组合物的组合物。 更具体地,本发明提供了包含病毒样颗粒和与其结合的至少一个Abeta1-6肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物,并有效诱导免疫应答,特别是抗体应答。 此外,本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。
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公开(公告)号:US20090246215A1
公开(公告)日:2009-10-01
申请号:US11905986
申请日:2007-10-05
申请人: Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
发明人: Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
CPC分类号: A61K39/0007 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64
摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇,特别是Abeta1-6肽-VLP组合物的组合物。 更具体地,本发明提供了包含病毒样颗粒和与其结合的至少一个Abeta1-6肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物,并有效诱导免疫应答,特别是抗体应答。 此外,本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。
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公开(公告)号:US20080274131A1
公开(公告)日:2008-11-06
申请号:US12010107
申请日:2008-01-18
申请人: Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
发明人: Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
CPC分类号: A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供包含有序重复抗原或抗原决定簇的组合物。 本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。 有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病,治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答,特别是抗体反应的药物的疫苗。
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公开(公告)号:US20120114674A1
公开(公告)日:2012-05-10
申请号:US13096970
申请日:2011-04-28
申请人: Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Lüönd , Matthias Staufenbiel , Peter Frey
发明人: Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Lüönd , Matthias Staufenbiel , Peter Frey
CPC分类号: A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供包含有序重复抗原或抗原决定簇的组合物。 本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。 有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病,治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答,特别是抗体反应的药物的疫苗。
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公开(公告)号:US07320793B2
公开(公告)日:2008-01-22
申请号:US10050898
申请日:2002-01-18
申请人: Wolfgang A Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
发明人: Wolfgang A Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
IPC分类号: A61K39/385 , A61K9/00 , A61K39/00 , A61K47/30
CPC分类号: A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供包含有序重复抗原或抗原决定簇的组合物。 本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。 有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病,治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答,特别是抗体反应的药物的疫苗。
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公开(公告)号:US10072624B2
公开(公告)日:2018-09-11
申请号:US14283479
申请日:2014-05-21
IPC分类号: F02M1/16 , F02N5/00 , F16D25/0635 , F16F15/134 , F16D48/02 , F16H45/02
CPC分类号: F02N5/00 , F16D25/0635 , F16D2048/0212 , F16F15/134 , F16H2045/0205 , F16H2045/0226 , F16H2045/0294
摘要: A starting element (100) for use, for example, in a drivetrain of a motor vehicle, includes a piston (310) which divides a first volume (560) that can be filled with a fluid from a second volume (570) that can be filled with a fluid, wherein the piston (310) comprises at least one fluid passage (640) which allows the fluid at least occasionally to pass through the piston (310) from the first volume (560) into the second volume (570) and/or from the second volume (570) into the first volume (560). The at least one fluid passage (640) comprises a passage component part (650) and a receiving opening (660) in the piston (310). The passage component part (650) is inserted into the receiving opening so that at least one passage opening (670) is formed which allows the fluid to pass through at least occasionally.
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公开(公告)号:US09453638B2
公开(公告)日:2016-09-27
申请号:US13985911
申请日:2012-02-20
申请人: Roland Fiederling , Peter Frey , Harald Kaps , Jenny Trommer
发明人: Roland Fiederling , Peter Frey , Harald Kaps , Jenny Trommer
IPC分类号: F21V29/00 , F21S8/10 , F21V23/00 , F21V29/02 , H05K1/02 , F21V21/00 , F21V29/70 , F21V29/76 , F21V29/90 , F21S2/00 , F21Y101/02 , F21Y105/00 , F21V29/67
CPC分类号: F21V29/70 , F21S2/005 , F21S41/141 , F21S43/14 , F21S45/30 , F21S45/43 , F21S45/60 , F21V21/00 , F21V23/006 , F21V23/008 , F21V29/02 , F21V29/677 , F21V29/763 , F21V29/90 , F21Y2101/00 , F21Y2105/00 , F21Y2115/10 , F21Y2115/15 , H05K1/0203 , H05K2201/10106
摘要: A semiconductor light-emitting module includes a housing, at least one cooling body accommodated in the housing wherein the cooling body is thermally connected to at least one semiconductor light source, an active cooling device accommodated in the housing, and at least one electronics unit accommodated in the housing, at least for actuating the at least one semiconductor light source, wherein the housing has a leadthrough opening, and the at least one semiconductor light source is arranged in the region of the leadthrough opening.
摘要翻译: 半导体发光模块包括壳体,容纳在壳体中的至少一个冷却体,其中冷却体热连接到至少一个半导体光源,容纳在壳体中的主动冷却装置,以及容纳至少一个电子单元 在壳体中,至少用于致动至少一个半导体光源,其中壳体具有引线开口,并且至少一个半导体光源布置在引导开口的区域中。
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公开(公告)号:US08870426B2
公开(公告)日:2014-10-28
申请号:US13259188
申请日:2010-03-29
申请人: Alois Biebl , Peter Frey , Ralf Vollmer
发明人: Alois Biebl , Peter Frey , Ralf Vollmer
CPC分类号: F21V25/00 , F21K9/00 , F21S41/192 , F21S45/48 , F21Y2115/10
摘要: An illumination unit for vehicle headlights may include a light-emitting diode device, a housing and an assembly board on which components of an operating circuit for operating the light-emitting diode device are arranged, wherein the housing and the assembly board define an interior space, wherein the assembly board has at least one electrically conductive inner layer that is connected to a ground reference potential of the operating circuit and on its surface the assembly board has at least one electrical contact surface which is contacted with at least one electrically conductive inner layer, and the housing has an electromagnetic shielding structure configured to provide electromagnetic shielding of the interior space, wherein the electromagnetic shielding structure is connected to the at least one electrical contact surface.
摘要翻译: 用于车辆前灯的照明单元可以包括发光二极管装置,壳体和组装板,其上布置有用于操作发光二极管装置的操作电路的部件,其中壳体和组装板限定内部空间 ,其中所述组装板具有至少一个导电内层,其连接到所述操作电路的接地参考电位,并且在其表面上,所述组装板具有至少一个电接触表面,所述至少一个电接触表面与至少一个导电内层 并且所述壳体具有电磁屏蔽结构,其构造成提供所述内部空间的电磁屏蔽,其中所述电磁屏蔽结构连接到所述至少一个电接触表面。
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公开(公告)号:US08186849B2
公开(公告)日:2012-05-29
申请号:US12230470
申请日:2008-08-29
申请人: Peter Helbig , Peter Frey , Ralf Vollmer
发明人: Peter Helbig , Peter Frey , Ralf Vollmer
IPC分类号: F21V33/00
CPC分类号: F21V19/0005 , F21K9/00 , F21V29/763 , F21Y2115/10 , H05K1/0203 , H05K1/0284 , H05K1/056 , H05K3/182 , H05K2201/09118 , H05K2201/10106 , Y10S362/80
摘要: A luminous module is specified comprising luminous units and a carrier body, wherein the luminous units are connected and/or contact-connected in at least two planes and/or orientations on the carrier body with conductor tracks. A method for producing the luminous module is furthermore specified.
摘要翻译: 发光模块被指定为包括发光单元和载体主体,其中发光单元以载体主体的至少两个平面和/或取向与导体轨迹连接和/或接触连接。 进一步说明发光模块的制造方法。
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