A method of joining two articles through a nano-enhanced joining medium is described. Nanomaterials are applied to the surfaces of sheets made of the joining medium via casting or spraying. Said sheets with nanomaterial coatings are then placed between the joining surfaces of the articles, and then application of pressure and heating is used to form a nano-engineered structural joint at the interface of said articles. The distinctly high specific surface area of nanomaterials and the energetic preference of their functionalized surfaces for bonding facilitate the joining process. Nano-engineered structural joints complement high strength levels with desired toughness and the compliance needed for accommodating deformation (e.g. thermal expansion) mismatches of joined articles without generating high stress levels near their interface. The limited quantity (per unit joint surface area) of nanomaterials utilized in nano-engineered joints benefits their economic viability.