发明申请
US20150376297A1 METHOD FOR REFOLDING ANTIBODY, PROCESS FOR PRODUCING REFOLDED ANTIBODY, REFOLDED ANTIBODY, AND USES THEREOF
有权
抗体抗体检测方法，生产抗体抗体的方法，抗体反应及其用途
- 专利标题： METHOD FOR REFOLDING ANTIBODY, PROCESS FOR PRODUCING REFOLDED ANTIBODY, REFOLDED ANTIBODY, AND USES THEREOF
- 专利标题（中）： 抗体抗体检测方法，生产抗体抗体的方法，抗体反应及其用途
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申请号： US14767373申请日： 2014-02-03
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公开(公告)号： US20150376297A1公开(公告)日： 2015-12-31
- 发明人: Yoichi Kumada , Yasuyuki Ishikawa , Yusuke Fujiwara , Michimasa Kishimoto
- 申请人： NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY
- 优先权： JP2013-027862 20130215
- 国际申请： PCT/JP2014/052475 WO 20140203
- 主分类号： C07K16/42
- IPC分类号： C07K16/42 ; C07K16/40 ; C08F122/10 ; C07K16/26 ; C07K17/08 ; C07K16/30 ; C07K16/18
摘要：
A method for refolding an antibody, a process for producing a refolded antibody, a refolded antibody, and uses thereof are provided. A method for refolding an antibody in a liquid phase comprises the steps of denaturing an inactive antibody binding directly or through a linker to a peptide, the peptide having an isoelectric point lower than the isoelectric point of the inactive antibody, and dispersing in a liquid phase the peptide-binding inactive antibody denatured in the step above. Also provided is a process for producing a refolded antibody.
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