Disclosed herein are implantable fistula treatment devices and related methods. In some embodiments, an anorectal fistula treatment device may comprise a disc- shaped distal anchor comprising a concave side and a convex side, an outer edge region, an inner sealing region protruding from the concave side, and an attachment region configured for attachment to a connecting member. The inner sealing region may have a greater thickness than at least a portion of the attachment region and the outer edge region may be oriented at an acute angle to the inner sealing region. The distal anchor may have a tapered edge and the outer edge region and inner sealing region may be configured to form separate seals against tissue about a distal opening of an anorectal fistula.