Invention Application
- Patent Title: INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
- Patent Title (中): 肾脏外部药物通道的抑制剂
-
Application No.: US14768245Application Date: 2014-02-12
-
Publication No.: US20160002259A1Publication Date: 2016-01-07
- Inventor: Alexander Pasternak , Reynalda Keh DeJesus , Fa-Xiang Ding , Shuzhi Dong , Jessica L. Frie , Xin Gu , Jinlong Jiang , Aurash Shahripour , Barbara Pio , Haifeng Tang , Shawn Walsh
- Applicant: Alexander PASTERNAK , Reynalda Keh DE JESUS , Fa-xiang DING , Shuzhi DONG , Jessica FRIE , Xin GU , Jinlong JIANG , Aurash SHAHRIPOUR , Barbara PIO , Haifeng TANG , Shawn WALSH , MERCK SHARP & DOHME CORP.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- International Application: PCT/US14/15901 WO 20140212
- Main IPC: C07D498/04
- IPC: C07D498/04 ; A61K45/06 ; A61K31/4985 ; A61K31/5383 ; C07D487/04
Abstract:
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure, kidney disease, edema, and conditions associated with excessive salt and water retention.
Public/Granted literature
- US09604998B2 Inhibitors of the renal outer medullary potassium channel Public/Granted day:2017-03-28
Information query
