摘要:
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.
摘要:
This invention relates to compounds having structural Formula (I); and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir 1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
摘要:
This invention provides compounds having the following general structure: This invention also provides pharmaceutical compositions comprising same and methods of using these compositions to treat and prevent disorders characterized by neuronal damage.
摘要:
There is provided a method for the detection of leaks of an electrophilic gas from a system, such as chlorodifluoromethane or carbon dioxide, which comprises applying to an exterior surface of the system a gel consisting essentially of a Lewis base capable of removing a proton from the gas or reacting therewith in a similar electrophilic manner; a dye capable of visibly indicating a color change on protonation or deprotonation; a solvent for the dye, the base and the gas; and a rheology modifier capable of producing a non-newtonian gel of all of these components which is sufficiently translucent to permit visual detection of change of color of the dye and of sufficient pseudoplasticity/thixotropy to provide adhesion to vertical and horizontal surfaces.
摘要:
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure, kidney disease, edema, and conditions associated with excessive salt and water retention.
摘要:
A computer-based fibre production monitoring system includes at least one sensor, and a computer server in communication with the sensors. Each sensor is configured to provide data packets each being associated with a respective threadline and providing a measurement of at least one physical characteristic of a fibre as it is drawn past the sensor on the threadline and wound onto a bobbin. The computer server is configured to provide an analysis of the physical characteristics on a per-threadline basis and/or per-bobbin basis from the measurements. The sensor is configured as an electric field sensor, and includes an insulating substrate, non-contacting electrodes disposed on the substrate, and vias extending transversely through the substrate. The electrodes are interlaced with one another. One portion of the vias is coupled to one portion of the electrodes, and another portion of the vias is coupled to another portion of the electrodes.
摘要:
There is provided a composition for the detection of an electrophilic gas, such as chlorodifluoromethane or carbon dioxide, which comprises a Lewis base capable of removing a proton from the gas or reacting therewith in a similar electrophilic manner; a dye capable of visibly indicating a color change on protonation or deprotonation; a solvent for the dye, the base and the gas; and a rheology modifier capable of producing a non-newtonian gel of all of these components which is sufficiently translucent to permit visual detection of change of color of the dye and of sufficient pseudoplasticity/thixotropy to provide adhesion to vertical and horizontal surfaces.
摘要:
This invention relates to compounds having structural Formula (I); and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir 1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
摘要:
An electric field sensor comprises an insulating substrate, a plurality of non-contacting electrodes disposed on the substrate, and a plurality of conductors coupled to the electrodes, and extending transversely through the substrate. The electrodes comprise a first electrode portion, and a second electrode portion interlaced with the first electrode portion. The conductors comprise a first conductor portion and a second conductor portion. The first portion of the conductors are coupled to the first electrode portion. The second portion of the conductors are coupled to the second electrode portion.
摘要:
The invention is directed to a method and apparatus for testing the qualityf pultruded material by measuring a load applied to the material as it is being pultruded and measuring the load associated with a fixed displacement of the pultruded stock material.