发明申请
- 专利标题： INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
- 专利标题（中）： 肾脏外部药物通道的抑制剂
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申请号： US14768245申请日： 2014-02-12
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公开(公告)号： US20160002259A1公开(公告)日： 2016-01-07
- 发明人: Alexander Pasternak , Reynalda Keh DeJesus , Fa-Xiang Ding , Shuzhi Dong , Jessica L. Frie , Xin Gu , Jinlong Jiang , Aurash Shahripour , Barbara Pio , Haifeng Tang , Shawn Walsh
- 申请人： Alexander PASTERNAK , Reynalda Keh DE JESUS , Fa-xiang DING , Shuzhi DONG , Jessica FRIE , Xin GU , Jinlong JIANG , Aurash SHAHRIPOUR , Barbara PIO , Haifeng TANG , Shawn WALSH , MERCK SHARP & DOHME CORP.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US14/15901 WO 20140212
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; A61K45/06 ; A61K31/4985 ; A61K31/5383 ; C07D487/04
摘要：
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure, kidney disease, edema, and conditions associated with excessive salt and water retention.
公开/授权文献
- US09604998B2 Inhibitors of the renal outer medullary potassium channel 公开/授权日：2017-03-28
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