发明申请
US20160039801A1 SUBSTITUTED ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
审中-公开
替代的醛类化合物及其在增加组织氧化中的用途
- 专利标题： SUBSTITUTED ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
- 专利标题（中）： 替代的醛类化合物及其在增加组织氧化中的用途
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申请号： US14776723申请日： 2014-03-14
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公开(公告)号： US20160039801A1公开(公告)日： 2016-02-11
- 发明人: Brian METCALF , Chihyuan CHUANG , Zhe LI
- 申请人： GLOBAL BLOOD THERAPEUTICS, INC. , CYTOKINETICS, INC.
- 申请人地址： US CA South San Francisco US CA South San Francisco
- 专利权人： CYTOKINETICS, INC.,GLOBAL BLOOD THERAPEUTICS, INC.
- 当前专利权人： CYTOKINETICS, INC.,GLOBAL BLOOD THERAPEUTICS, INC.
- 当前专利权人地址： US CA South San Francisco US CA South San Francisco
- 国际申请： PCT/US2014/029682 WO 20140314
- 主分类号： C07D405/14
- IPC分类号： C07D405/14 ; C07C62/36 ; C07D231/12 ; C07D233/64 ; C07D401/12 ; C07D405/04 ; C07D213/61 ; C07C47/575 ; C07D213/65 ; C07C69/757 ; C07D213/64
摘要：
Provided are cycloalkyl- and cycloalkenyl-substituted benzaldehydes and heteroaldehydes of formula (I) that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions containing the modulators, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from increased tissue oxygenation.
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