发明申请
- 专利标题： POTENT NON-UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE
- 专利标题（中）： 可溶性环氧化物水解物的非尿素抑制剂
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申请号： US14930409申请日： 2015-11-02
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公开(公告)号： US20160052883A1公开(公告)日： 2016-02-25
- 发明人: Donald W. Landry , Yuli Xie , Yidong Liu , Gangli Gong , Shi-Xian Deng , Kirsten Alison Rinderspacher
- 申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 申请人地址： US NY New York
- 专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人地址： US NY New York
- 主分类号： C07D211/96
- IPC分类号： C07D211/96
摘要：
The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.
公开/授权文献
- US10005732B2 Potent non-urea inhibitors of soluble epoxide hydrolase 公开/授权日：2018-06-26
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