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公开(公告)号:US20180305314A1
公开(公告)日:2018-10-25
申请号:US16018770
申请日:2018-06-26
发明人: Donald W. Landry , Yuli Xie , Yidong Liu , Gangli Gong , Shi-Xian Deng , Kirsten Alison Rinderspacher
IPC分类号: C07D211/96 , C07F9/59 , C07D211/62 , C12N9/99 , C07D401/12 , C07D409/12
CPC分类号: C07D211/96 , C07D211/62 , C07D401/12 , C07D409/12 , C07F9/59 , C12N9/99
摘要: The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.
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公开(公告)号:US10005732B2
公开(公告)日:2018-06-26
申请号:US14930409
申请日:2015-11-02
发明人: Donald W. Landry , Yuli Xie , Yidong Liu , Gangli Gong , Shi-Xian Deng , Kirsten Alison Rinderspacher
IPC分类号: C07D211/96 , C07D211/62 , C07D401/12 , C07D409/12 , C12N9/99 , C07F9/59
CPC分类号: C07D211/96 , C07D211/62 , C07D401/12 , C07D409/12 , C07F9/59 , C12N9/99
摘要: The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.
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公开(公告)号:US20160052883A1
公开(公告)日:2016-02-25
申请号:US14930409
申请日:2015-11-02
发明人: Donald W. Landry , Yuli Xie , Yidong Liu , Gangli Gong , Shi-Xian Deng , Kirsten Alison Rinderspacher
IPC分类号: C07D211/96
CPC分类号: C07D211/96 , C07D211/62 , C07D401/12 , C07D409/12 , C07F9/59 , C12N9/99
摘要: The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.
摘要翻译: 本发明涉及通过抑制可溶性环氧化物水解酶(sEH)的活性而显示血管扩张和抗炎作用的化合物。 本发明还涉及鉴定这些化合物的方法,以及这些化合物用于治疗与血管舒张功能障碍,炎症和/或内皮细胞相关的疾病的用途。 特别是非限制性实施方案,本发明的组分可用于治疗高血压。
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公开(公告)号:US20200216469A1
公开(公告)日:2020-07-09
申请号:US16818388
申请日:2020-03-13
IPC分类号: C07D513/04 , A61P25/28 , C07D491/048 , C07D401/12 , C07D239/88 , C07D217/22 , A61K31/517 , C07D495/04 , C07D491/04 , C07D471/04 , C07D239/94 , C07D239/93 , C07D239/86 , C07D405/12 , C07D403/12
摘要: The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.
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公开(公告)号:US20190112317A1
公开(公告)日:2019-04-18
申请号:US15765801
申请日:2016-10-05
IPC分类号: C07D513/04 , A61K31/517 , C07D217/22 , C07D239/88 , C07D239/93 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D491/048 , A61P25/28
摘要: The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.
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公开(公告)号:US20180312526A1
公开(公告)日:2018-11-01
申请号:US16027930
申请日:2018-07-05
IPC分类号: C07D513/04 , C07D491/048 , C07D401/12 , C07D217/22 , C07D239/88 , C07D495/04 , C07D405/12 , C07D471/04 , C07D239/94 , C07D239/93 , A61K31/517 , C07D403/12 , C07D239/86 , C07D491/04
CPC分类号: C07D513/04 , A61K31/517 , C07D217/22 , C07D239/86 , C07D239/88 , C07D239/93 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要: The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.
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公开(公告)号:US20140336193A1
公开(公告)日:2014-11-13
申请号:US14339183
申请日:2014-07-23
IPC分类号: C07D211/96 , C07D405/12 , C07D401/12
CPC分类号: C07D211/96 , C07D401/12 , C07D405/12
摘要: The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.
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公开(公告)号:US20170210759A1
公开(公告)日:2017-07-27
申请号:US15480220
申请日:2017-04-05
IPC分类号: C07D513/04 , C07D239/94 , C07D239/86 , C07D401/12 , C07D491/048 , C07D405/12 , C07D495/04 , C07D239/88 , C07D217/22 , C07D471/04 , C07D403/12 , C07D239/93
CPC分类号: C07D513/04 , A61K31/517 , A61P25/28 , C07D217/22 , C07D239/86 , C07D239/88 , C07D239/93 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要: The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.
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公开(公告)号:US09175285B2
公开(公告)日:2015-11-03
申请号:US14182175
申请日:2014-02-17
发明人: Donald W. Landry , Yuli Xie , Yidong Lu , Gangli Gong , Shi-Xian Deng , Kirsten Alison Rinderspacher
IPC分类号: C12N9/99 , C07D211/96 , C07D401/12 , C07D409/12 , C07D211/62 , C07F9/59
CPC分类号: C07D211/96 , C07D211/62 , C07D401/12 , C07D409/12 , C07F9/59 , C12N9/99
摘要: The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.
摘要翻译: 本发明涉及通过抑制可溶性环氧化物水解酶(sEH)的活性而显示血管扩张和抗炎作用的化合物。 本发明还涉及鉴定这些化合物的方法,以及这些化合物用于治疗与血管舒张功能障碍,炎症和/或内皮细胞相关的疾病的用途。 特别是非限制性实施方案,本发明的组分可用于治疗高血压。
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公开(公告)号:US20140349368A1
公开(公告)日:2014-11-27
申请号:US14182175
申请日:2014-02-17
发明人: Donald W. Landry , Yuli Xie , Yidong Lu , Gangli Gong , Shi-Xian Deng , Kirsten Alison Rinderspacher
IPC分类号: C12N9/99 , C07F9/59 , C07D409/12 , C07D211/62 , C07D211/96 , C07D401/12
CPC分类号: C07D211/96 , C07D211/62 , C07D401/12 , C07D409/12 , C07F9/59 , C12N9/99
摘要: The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.
摘要翻译: 本发明涉及通过抑制可溶性环氧化物水解酶(sEH)的活性而显示血管扩张和抗炎作用的化合物。 本发明还涉及鉴定这些化合物的方法,以及这些化合物用于治疗与血管舒张功能障碍,炎症和/或内皮细胞相关的疾病的用途。 特别是非限制性实施方案,本发明的组分可用于治疗高血压。
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