Invention Application
US20160083349A1 PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
有权
吡啶-2（1H） - 酮喹诺酮衍生物作为突变型脱氢酶抑制剂
- Patent Title: PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
- Patent Title (中): 吡啶-2（1H） - 酮喹诺酮衍生物作为突变型脱氢酶抑制剂
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Application No.: US14858174Application Date: 2015-09-18
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Publication No.: US20160083349A1Publication Date: 2016-03-24
- Inventor: Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
- Applicant: Forma Therapeutics, Inc.
- Main IPC: C07D215/227
- IPC: C07D215/227 ; C07D401/12
Abstract:
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R8 are described herein.
Public/Granted literature
- US10005734B2 Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors Public/Granted day:2018-06-26
Information query
