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公开(公告)号：US11498913B2
公开(公告)日：2022-11-15
申请号：US17101018
申请日：2020-11-23
Applicant: FORMA Therapeutics, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
IPC: C07D401/12 , C07D401/14 , C07D471/04 , A61P35/00 , A61K31/47
Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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公开(公告)号：US20220073525A1
公开(公告)日：2022-03-10
申请号：US17417805
申请日：2019-12-27
Applicant: FORMA Therapeutics, Inc.
Inventor： Alexandre Joseph Buckmelter , Justin Andrew Caravella , Jian Lin , Edward L. Fritzen
IPC: C07D487/04
Abstract: This disclosure relates to modulating ubiquitin specific protease 1 (USP1) and provides novel chemical compounds useful as inhibitors of USP1, as well as various uses of these compounds. USP1 inhibiting compounds are useful in the treatment of diseases and disorders associated with USP1, such as cancer.
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公开(公告)号：US10889567B2
公开(公告)日：2021-01-12
申请号：US16712951
申请日：2019-12-12
Applicant: FORMA Therapeutics, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
IPC: C07D401/12 , C07D401/14 , C07D471/04 , A61P35/00 , A61K31/47
Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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公开(公告)号：US20180134682A1
公开(公告)日：2018-05-17
申请号：US15712446
申请日：2017-09-22
Applicant: FORMA Therapeutics, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
IPC: C07D401/12 , C07D405/14 , C07D401/14 , C07D403/12 , C07D471/04 , C07D409/14 , C07D413/14 , C07D417/14
CPC classification number: C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R6 are described herein.
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公开(公告)号：US20180086733A1
公开(公告)日：2018-03-29
申请号：US15677748
申请日：2017-08-15
Applicant: FORMA Therapeutics, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
IPC: C07D401/12 , C07D417/14 , C07D413/14 , C07D405/14 , C07D401/14 , A61K31/4704
CPC classification number: C07D401/12 , A61K31/4704 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.
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Patent Agency Ranking
6.发明申请PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS 有权吡啶-2（1H） - 酮喹诺酮衍生物作为突变型脱氢酶抑制剂公开(公告)号：US20160083349A1
公开(公告)日：2016-03-24
申请号：US14858174
申请日：2015-09-18
Applicant: Forma Therapeutics, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
IPC: C07D215/227 , C07D401/12
CPC classification number: C07D215/227 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R8 are described herein.
Abstract translation: 本发明涉及用于治疗细胞增殖障碍和癌症的具有新形态活性的突变异柠檬酸脱氢酶（mt-IDH）蛋白的抑制剂，其具有下式：其中A，B，W1，W2，W3和R1-R8是 在此描述。
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7.发明公开公开(公告)号：US20240150319A1
公开(公告)日：2024-05-09
申请号：US18506060
申请日：2023-11-09
Applicant: FORMA Therapeutics, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
IPC: C07D401/12 , A61P35/00 , C07D401/14 , C07D471/04
CPC classification number: C07D401/12 , A61P35/00 , C07D401/14 , C07D471/04 , A61K31/47
Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula:
where A, U, W1, W2, W3, R1-R6, and R9 are described herein.-
公开(公告)号：US20230125739A1
公开(公告)日：2023-04-27
申请号：US17984069
申请日：2022-11-09
Applicant: FORMA Therapeutics, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
IPC: C07D401/12 , C07D401/14 , C07D471/04 , A61P35/00
Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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公开(公告)号：US11161848B2
公开(公告)日：2021-11-02
申请号：US16540327
申请日：2019-08-14
Applicant: FORMA Therapeutics, Inc.
Inventor： Alexandre Joseph Buckmelter , Stephanos Ioannidis , Bruce Follows , Gary Gustafson , Minghua Wang , Justin A. Caravella , Zhongguo Wang , Edward L. Fritzen , Jian Lin
IPC: C07D473/00 , A61K31/522
Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.
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公开(公告)号：US20210078973A1
公开(公告)日：2021-03-18
申请号：US17101018
申请日：2020-11-23
Applicant: FORMA Therapeutics, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
IPC: C07D401/12 , C07D401/14 , C07D471/04 , A61P35/00
Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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