In accordance with embodiments disclosed herein, there is provided systems and methods for providing a post-processing mechanism for physically unclonable functions. An integrated circuit includes a physically unclonable function (PUF) unit including an adaptive PUF logic. The adaptive PUF logic receives a PUF response having a plurality of bits. The adaptive PUF logic also determines whether a record exists for bit among the plurality of bits in the PUF response. The record includes a stored bit location and a stored bit value corresponding to the stored bit location. The adaptive PUF logic also overrides a bit value of the bit in the PUF response with the stored bit value when it is determined that the record exists for the bit in the PUF response. The bit value of the bit in the PUF response is different from the stored bit value.