A method and system determine, during movement of a vehicle system along a route, a tractive load demanded by the vehicle system to propel the vehicle system along the route. The vehicle system includes a propulsion-generating vehicle having plural individually controllable traction motors. A first selected set of the traction motors for deactivation is identified during the movement of the vehicle system along the route based at least in part on the tractive load demanded by the vehicle system. The traction motors in the first selected set are deactivated while at least one of the traction motors in a first remaining set of the traction motors continues to generate tractive effort to propel the vehicle system. The traction motors that are selected for deactivation may all be on the same vehicle in the vehicle system, or may be on different vehicles of the same vehicle system.