发明申请
US20160090629A1 VARIANTS OF TNFSF15 AND DCR3 ASSOCIATED WITH CROHN'S DISEASE
审中-公开
与CROHN病相关的TNFSF15和DCR3的变异
- 专利标题： VARIANTS OF TNFSF15 AND DCR3 ASSOCIATED WITH CROHN'S DISEASE
- 专利标题（中）： 与CROHN病相关的TNFSF15和DCR3的变异
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申请号： US14890712申请日： 2014-05-16
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公开(公告)号： US20160090629A1公开(公告)日： 2016-03-31
- 发明人: Dermot P. McGovern
- 申请人： CEDARS-SINAI MEDICAL CENTER
- 申请人地址： US CA Los Angeles
- 专利权人： CEDARS-SINAI MEDICAL CENTER
- 当前专利权人： CEDARS-SINAI MEDICAL CENTER
- 当前专利权人地址： US CA Los Angeles
- 国际申请： PCT/US14/38468 WO 20140516
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
Described herein are methods and compositions related to the discovery of associations in TNFSF15 15 and DcR3 genetic loci across in Caucasian, Puerto Rican, and Korean Crohn's Disease, as demonstrated via trans-ethnic fine mapping. The present invention provides methods of quantifying risk and diagnosing susceptibility to Crohn's disease in a subject by determining the presence of one or more risk variants are at the TNFSF15 (or TL1A) and/or DcR3 genetic loci.
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