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    DEEP LEARNING-BASED ATTENUATION CORRECTION OF CARDIAC IMAGING DATA
    8.
    发明公开
    DEEP LEARNING-BASED ATTENUATION CORRECTION OF CARDIAC IMAGING DATA 审中-公开

    公开(公告)号：US20240095912A1

    公开(公告)日：2024-03-21

    申请号：US18367154

    申请日：2023-09-12

    申请人： CEDARS-SINAI MEDICAL CENTER

    发明人： Piotr SLOMKA ,  Aakash Shanbhag

    IPC分类号： G06T7/00

    CPC分类号： G06T7/0012 ,  G06T2207/10108 ,  G06T2207/20081 ,  G06T2207/30048

    摘要： Systems and methods are disclosed for applying attenuation correction to single photon emission computed tomography (SPECT) imaging data for myocardial perfusion imaging (MPI) studies. SPECT-MPI imaging data can be provided to a deep-learning model to automatically generate simulated computed tomography attenuation correction (CT-AC) images from the non-corrected (NC) SPECT-MPI imaging data. These simulated CT-AC images can then be used to perform attenuation correction on the SPECT-MPI imaging data to generate corrected SPECT-MPI imaging data. The deep-learning model can be trained using corresponding pairs of non-corrected SPECT-MPI imaging data and traditional CT-AC imaging data. The deep-learning model can be a conditional generative adversarial neural network (cGAN).

    In vitro induction of mammary-like differentiation from human pluripotent stem cells
    9.
    发明授权
    In vitro induction of mammary-like differentiation from human pluripotent stem cells 有权

    公开(公告)号：US11913022B2

    公开(公告)日：2024-02-27

    申请号：US16480778

    申请日：2018-01-25

    申请人： Cedars-Sinai Medical Center

    发明人： Ying Qu ,  Xiaojiang Cui ,  Dhruv Sareen ,  Armando E. Giuliano

    IPC分类号： A61K35/55 ,  C12N5/071 ,  C12N5/074

    CPC分类号： C12N5/0631 ,  A61K35/55 ,  C12N5/0696 ,  C12N2506/45 ,  C12N2533/54 ,  C12N2533/90

    摘要： Human induced pluripotent stem cells (iPSCs) can give rise to multiple cell types and hold great promise in regenerative medicine and disease modeling applications. The Inventors herein developed a reliable two-step protocol to generate human mammary-like organoids from iPSCs. Non-neural ectoderm cell-containing spheres, referred to as mEBs, were first differentiated and enriched from iPSCs using MammoCult medium. Gene expression profile analysis suggested that mammary gland function-associated signaling pathways were hallmarks of 10-d differentiated mEBs. The Inventors generated mammary-like organoids from 10-d mEBs using 3D floating mixed gel culture and a three-stage differentiation procedure. These organoids expressed common breast tissue, luminal, and basal markers, including estrogen receptor, and could be induced to produce milk protein. These results demonstrate that human iPSCs can be directed in vitro toward mammary lineage differentiation.