A method of manufacturing a sole with shoe nails made of different materials is provided. The method includes pre-forming shoe nails, putting the shoe nails in an injection molding mold, applying a surface treatment agent and an adhesive glue, injecting the heated molten sole material into a mold, binding the sole material and the shoe nails with the adhesive glue, and performing a cooling process to cause the sole material to solidify and turn into a sole and cause the adhesive glue to solidify and couple the sole and shoe nails together. The method enables a sole with shoe nails to be quickly manufactured so easily that it increases production efficiency and economic benefits.