Disclosed is a method of driving a radiation detection apparatus using a variable voltage applying scheme. In the method, different voltages are applied in a standby step, where radiation is not irradiated onto the radiation detection apparatus, and an irradiation step where the radiation is irradiated. A voltage which is applied in the standby step has an absolute value lower than a voltage which is applied in the irradiation step, and is set to minimize a dark current which is generated in a photoconductor layer of the radiation detection apparatus in the standby step.