A system for controlling a vacuum pump in a gasoline vehicle with a clutch includes a clutch installed between a driving source supplying power of an engine and a vacuum pump to selectively interrupt the power supplied from the driving source to the vacuum pump. A pressure sensor is configured to sense a pressure of a vacuum line installed between the vacuum pump and a brake booster. A controller is configured to compare the pressure measured by the pressure sensor with a target pressure value to selectively interrupt the clutch.