Invention Application
US20160122772A1 Production of Polypeptides Without Secretion Signal in Bacillus
审中-公开
芽孢杆菌中不分泌信号的多肽的生产
- Patent Title: Production of Polypeptides Without Secretion Signal in Bacillus
- Patent Title (中): 芽孢杆菌中不分泌信号的多肽的生产
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Application No.: US14896423Application Date: 2014-06-23
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Publication No.: US20160122772A1Publication Date: 2016-05-05
- Inventor: Niels Banke , Michael Dolberg Rasmussen , Poul Erik Pedersen , Martin Simon Borchert
- Applicant: Novozymes A/S
- Applicant Address: DK Bagsvaerd
- Assignee: Novozymes A/S
- Current Assignee: Novozymes A/S
- Current Assignee Address: DK Bagsvaerd
- International Application: PCT/EP2014/063184 WO 20140623
- Main IPC: C12N15/75
- IPC: C12N15/75 ; C12N9/10 ; C12N9/82 ; C12P21/00
Abstract:
The present invention relates to a method of producing a natively non-secreted polypeptide without a secretion signal in a Bacillus host cell and recovering the polypeptide without performing a lysis step as well as to a Bacillus host cell comprising one or more exogenous or heterologous polynucleotides encoding a natively non-secreted polypeptide with no secretion signal.
Information query
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