A system and method for positioning radioactive material are provided. A scanning and imaging apparatus comprises a ray source configured to generate an X-ray and a detection device configured to receive an X-ray transmitted through an inspected object, wherein the ray source is configured to image the inspected object by emitting the X-ray to the inspected object. A radioactivity detector is configured to detect whether the inspected object comprises radioactive material synchronously with the process of scanning implemented by the scanning and imaging apparatus. In a case that the radioactive detector detects radioactive material, an actual position of the radioactive material in an X-ray image of the inspected object obtained by the scanning and imaging apparatus is marked in the image. The above solutions improve the accuracy of displaying the position of the radioactive source in the X-ray image. Further, inspection of radioactive material can be implemented while scanning an image. In this way, an error in the correspondence between inspection results of two systems when the two systems operate independently is avoided.