Disclosed are a method and system for indicating sub-frame configuration in D2D communication. The method includes that a configured D2D transmitting sub-frame and/or D2D receiving sub-frame and/or D2D special sub-frame are indicated through high layer signalling and/or physical layer signalling, wherein the D2D transmitting sub-frame is for carrying and transmitting D2D communication data, the D2D receiving sub-frame is for receiving D2D communication data and the D2D special sub-frame is for carrying, transmitting and receiving D2D communication data; and the D2D transmitting sub-frame, receiving sub-frame and special sub-frame are system uplink sub-frames.