发明申请
US20160137661A1 SYNTHETIC PROCESS FOR PREPARATION OF MACROCYCLIC C1-KETO ANALOGS OF HALICHONDRIN B AND INTERMEDIATES USEFUL THEREIN INCLUDING INTERMEDIATES CONTAINING -SO2-(P-TOLYL) GROUPS
有权
用于制备哈利金曲霉B的大分子C1-KETO类似物的合成方法及其有用的中间体，包括含有-SO2-（P-TOLYL）基团的中间体
- 专利标题： SYNTHETIC PROCESS FOR PREPARATION OF MACROCYCLIC C1-KETO ANALOGS OF HALICHONDRIN B AND INTERMEDIATES USEFUL THEREIN INCLUDING INTERMEDIATES CONTAINING -SO2-(P-TOLYL) GROUPS
- 专利标题（中）： 用于制备哈利金曲霉B的大分子C1-KETO类似物的合成方法及其有用的中间体，包括含有-SO2-（P-TOLYL）基团的中间体
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申请号： US14901481申请日： 2014-05-30
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公开(公告)号： US20160137661A1公开(公告)日： 2016-05-19
- 发明人: Fabio E.S. SOUZA , Alena RUDOLPH , Dino ALBERICO , Robert JORDAN , Ming PAN , Boris GORIN
- 申请人： ALPHORA RESEARCH INC.
- 国际申请： PCT/CA2014/050504 WO 20140530
- 主分类号： C07D493/04
- IPC分类号： C07D493/04 ; C07D407/14 ; C07D307/20 ; C07D407/06
摘要：
Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7′, R8, R9, R10, R11, R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.