发明申请
- 专利标题： DOSAGE COMPENSATING TRANSGENES AND CELLS
- 专利标题（中）： 剂量补充转基因和细胞
-
申请号： US14776672申请日： 2014-03-14
-
公开(公告)号： US20160143951A1公开(公告)日： 2016-05-26
- 发明人: Jeanne B. Lawrence , Jun Jiang , Lisa L. Hall
- 申请人： UNIVERSITY OF MASSACHUSETTS
- 国际申请： PCT/US14/27525 WO 20140314
- 主分类号： A61K35/28
- IPC分类号： A61K35/28 ; C12N15/85
摘要：
Methods and compositions for reducing expression of genes on Chromosome 21 (“Chr 21”) by targeting an XIST transgene to the Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene or a Regulator of calcineurin 1 (RCAN1) gene, and cells and transgenic animals comprising an XIST transgene inserted into a DYRK1A or RCAN1 allele, e.g., cells and animals trisomic for human Chr 21 and mouse Chr 16.
公开/授权文献
- US10004765B2 Dosage compensating transgenes and cells 公开/授权日：2018-06-26