发明申请
US20160159866A1 CLOSTRIDIAL NEUROTOXIN FUSION PROTEINS, PROPEPTIDE FUSIONS, THEIR EXPRESSION, AND USE
审中-公开
封闭神经毒素融合蛋白，丙型肝炎融合蛋白，其表达和用途
- 专利标题： CLOSTRIDIAL NEUROTOXIN FUSION PROTEINS, PROPEPTIDE FUSIONS, THEIR EXPRESSION, AND USE
- 专利标题（中）： 封闭神经毒素融合蛋白，丙型肝炎融合蛋白，其表达和用途
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申请号： US14964146申请日： 2015-12-09
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公开(公告)号： US20160159866A1公开(公告)日： 2016-06-09
- 发明人: Konstantin Ichtchenko , Edwin Vazquez-Cintron , Philip A. Band , Timothy J. Cardozo
- 申请人： Konstantin Ichtchenko , Edwin Vazquez-Cintron , Philip A. Band , Timothy J. Cardozo
- 申请人地址： US NY New York
- 专利权人： New York University
- 当前专利权人： New York University
- 当前专利权人地址： US NY New York
- 主分类号： C07K14/33
- IPC分类号： C07K14/33
摘要：
The present invention is directed to a fusion protein comprising a light chain region of a Clostridial neurotoxin and a heavy chain region of a Clostridial neurotoxin, where the light and heavy chain regions are linked by a disulfide bond. The fusion protein also has a single chain antibody positioned upstream of the light chain region, where the single chain antibody possesses antigen-binding activity. Also disclosed are therapeutic agents, treatment methods, propeptide fusions, isolated nucleic acid molecules, expression systems, host cells, and methods of expressing fusion proteins.
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