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1.发明申请CLOSTRIDIAL NEUROTOXIN FUSION PROTEINS, PROPEPTIDE FUSIONS, THEIR EXPRESSION, AND USE 审中-公开封闭神经毒素融合蛋白，丙型肝炎融合蛋白，其表达和用途公开(公告)号：US20160159866A1
公开(公告)日：2016-06-09
申请号：US14964146
申请日：2015-12-09
IPC分类号： C07K14/33
CPC分类号： C07K14/33 , A61K2039/505 , C07K16/1282 , C07K2317/622 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/41 , C07K2319/50
摘要： The present invention is directed to a fusion protein comprising a light chain region of a Clostridial neurotoxin and a heavy chain region of a Clostridial neurotoxin, where the light and heavy chain regions are linked by a disulfide bond. The fusion protein also has a single chain antibody positioned upstream of the light chain region, where the single chain antibody possesses antigen-binding activity. Also disclosed are therapeutic agents, treatment methods, propeptide fusions, isolated nucleic acid molecules, expression systems, host cells, and methods of expressing fusion proteins.
摘要翻译： 本发明涉及包含梭菌神经毒素的轻链区和梭菌神经毒素的重链区的融合蛋白，其中轻链和重链区通过二硫键连接。 融合蛋白还具有位于轻链区域上游的单链抗体，其中单链抗体具有抗原结合活性。 还公开了治疗剂，治疗方法，前肽融合物，分离的核酸分子，表达系统，宿主细胞和表达融合蛋白的方法。
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2.发明授权Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated RNA decay 有权与无义介导的RNA衰变相关的遗传疾病的药物组合物和治疗公开(公告)号：US09216180B2
公开(公告)日：2015-12-22
申请号：US14044457
申请日：2013-10-02
IPC分类号： A61K31/535 , A61K31/415 , A61K31/505 , A61K31/53 , A61K31/4152 , A61K45/06 , G01N33/50 , G06F19/12 , A61K31/167 , A61K31/34 , A61K31/381 , A61K31/4035 , A61K31/4184 , A61K31/4192 , A61K31/433 , A61K31/445 , A61K31/513 , A61K31/538 , G06F19/16 , G06F19/00
CPC分类号： A61K31/53 , A61K31/167 , A61K31/34 , A61K31/381 , A61K31/40 , A61K31/4035 , A61K31/415 , A61K31/4152 , A61K31/4155 , A61K31/4184 , A61K31/4192 , A61K31/4245 , A61K31/433 , A61K31/44 , A61K31/445 , A61K31/498 , A61K31/50 , A61K31/513 , A61K31/536 , A61K31/538 , A61K45/06 , G01N33/5023 , G06F19/12 , G06F19/16 , G06F19/706 , Y02A90/26
摘要： The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating a genetic disease caused by premature termination codons, or other conditions that render messenger ribonucleic acid (mRNA) susceptible to nonsense mediated RNA decay, in a subject. Also disclosed is a method of inhibiting nonsense mediated RNA decay and/or induction of autophagy. The present invention also relates to a method of identifying inhibitors of nonsense mediated RNA decay and/or inducing autophagy. The present invention further relates to a method of inhibiting nonsense mediated RNA decay and/or induction of autophagy in a subject.
摘要翻译： 本发明涉及包含化合物和药学上可接受的载体的药物组合物。 本发明还涉及一种治疗由过早终止密码子引起的遗传疾病的方法或在受试者中使信使核糖核酸（mRNA）易于无义介导的RNA衰变的其它病症。 还公开了抑制无义介导的RNA衰变和/或诱导自噬的方法。 本发明还涉及鉴定无义介导的RNA衰变和/或诱导自噬的抑制剂的方法。 本发明还涉及抑制无症状介导的RNA衰变和/或受试者自噬诱导的方法。
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3.发明授权Immunogen comprising the HIV GP120 V3 loop in a conformation that induces broadly neutralizing antibodies 有权包含诱导广泛中和抗体的构象的HIV GP120 V3环的免疫原公开(公告)号：US08961987B2
公开(公告)日：2015-02-24
申请号：US12195318
申请日：2008-08-20
申请人： Susan Zolla-Pazner , Miroslaw K. Gorny , Timothy J. Cardozo , Xiang-peng Kong , Ruben Abagyan , Maxim Totrov , Shan Lu , Abraham Pinter
发明人： Susan Zolla-Pazner , Miroslaw K. Gorny , Timothy J. Cardozo , Xiang-peng Kong , Ruben Abagyan , Maxim Totrov , Shan Lu , Abraham Pinter
CPC分类号： C07K14/005 , A61K38/03 , A61K38/16 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , C07K2319/35 , C07K2319/55 , C12N2740/16122 , C12N2740/16134 , Y02A50/472
摘要： Insertion of HIV-1 V3 loop peptides from the viral glycoprotein gp120 into selected, immunogenic scaffold proteins results in a recombinant polypeptide that is a potent V3 immunogen. V3 immunogens include natural and consensus V3 sequences and cyclic and reverse peptides. Preferred scaffold proteins are Cholera Toxin subunit B and homologues thereof including closely related E. coli enterotoxins. Such immunogenic polypeptides induce broadly reactive anti-gp120 antibodies specific for V3 epitopes that can neutralize heterologous HIV-1 subtypes and strains. These polypeptide, methods for preparing them, and methods for inducing anti-gp120 (V3-specific) antibody) responses using them are disclosed.
摘要翻译： 将HIV-1 V3环肽从病毒糖蛋白gp120插入到选定的免疫原性支架蛋白中导致重组多肽，其是有效的V3免疫原。 V3免疫原包括天然和共有的V3序列和环状和反向肽。 优选的支架蛋白是霍乱毒素亚基B及其同系物，包括密切相关的大肠杆菌肠毒素。 这样的免疫原性多肽诱导可以中和异源HIV-1亚型和菌株的V3表位特异性的广泛反应性抗gp120抗体。 公开了这些多肽，其制备方法和诱导抗gp120（V3特异性）抗体的方法）。
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4.发明申请PHARMACEUTICAL COMPOSITIONS AND TREATMENT OF GENETIC DISEASES ASSOCIATED WITH NONSENSE MEDIATED RNA DECAY 有权药物组合物和与非神经介导的RNA衰减相关的遗传病的治疗公开(公告)号：US20140094457A1
公开(公告)日：2014-04-03
申请号：US14044457
申请日：2013-10-02
IPC分类号： A61K31/53 , G06F19/12 , G01N33/50 , A61K31/4152 , A61K45/06
CPC分类号： A61K31/53 , A61K31/167 , A61K31/34 , A61K31/381 , A61K31/40 , A61K31/4035 , A61K31/415 , A61K31/4152 , A61K31/4155 , A61K31/4184 , A61K31/4192 , A61K31/4245 , A61K31/433 , A61K31/44 , A61K31/445 , A61K31/498 , A61K31/50 , A61K31/513 , A61K31/536 , A61K31/538 , A61K45/06 , G01N33/5023 , G06F19/12 , G06F19/16 , G06F19/706 , Y02A90/26
摘要： The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating a genetic disease caused by premature termination codons, or other conditions that render messenger ribonucleic acid (mRNA) susceptible to nonsense mediated RNA decay, in a subject. Also disclosed is a method of inhibiting nonsense mediated RNA decay and/or induction of autophagy. The present invention also relates to a method of identifying inhibitors of nonsense mediated RNA decay and/or inducing autophagy. The present invention further relates to a method of inhibiting nonsense mediated RNA decay and/or induction of autophagy in a subject.
摘要翻译： 本发明涉及包含化合物和药学上可接受的载体的药物组合物。 本发明还涉及一种治疗由过早终止密码子引起的遗传疾病的方法或在受试者中使信使核糖核酸（mRNA）易于无义介导的RNA衰变的其它病症。 还公开了抑制无义介导的RNA衰变和/或诱导自噬的方法。 本发明还涉及鉴定无义介导的RNA衰变和/或诱导自噬的抑制剂的方法。 本发明还涉及抑制无症状介导的RNA衰变和/或受试者自噬诱导的方法。
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5.发明授权Method of orally treating inflammatory skin conditions with prodrugs of 5-fluorouracil 有权用5-氟尿嘧啶前药口服治疗炎症皮肤病的方法公开(公告)号：US07026301B2
公开(公告)日：2006-04-11
申请号：US10689530
申请日：2003-10-17
申请人： Timothy J. Cardozo , John C. Pui
发明人： Timothy J. Cardozo , John C. Pui
IPC分类号： A61K3/7072 , A61K3/513
CPC分类号： A61K31/7072 , A61K31/513
摘要： The present invention relates to the treatment of inflammatory skin conditions, including psoriasis, with a prodrug of 5-fluorouracil. The invention relates to methods for treatment of psoriasis with capecitabine, an oral prodrug of 5-fluorouracil.
摘要翻译： 本发明涉及用5-氟尿嘧啶的前体药物治疗炎性皮肤病，包括牛皮癣。 本发明涉及用卡培他滨治疗牛皮癣的方法，该药是5-氟尿嘧啶的口服前体药物。
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6.发明申请IMMUNOGEN PRESENTING HIV GP120 V3 LOOP IN A CONFORMATION THAT INDUCES BROADLY NEUTRALIZING ANTIBODIES 有权免疫细胞提供HIV GP120 V3环路，诱导大量中和抗体公开(公告)号：US20090098144A1
公开(公告)日：2009-04-16
申请号：US12195318
申请日：2008-08-20
申请人： Susan ZOLLA-PAZNER , Miroslaw K. Gorny , Timothy J. Cardozo , Xiang-peng Kong , Ruben Abagyan , Maxim Totrov , Shan Lu , Abraham Pinter
发明人： Susan ZOLLA-PAZNER , Miroslaw K. Gorny , Timothy J. Cardozo , Xiang-peng Kong , Ruben Abagyan , Maxim Totrov , Shan Lu , Abraham Pinter
CPC分类号： C07K14/005 , A61K38/03 , A61K38/16 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , C07K2319/35 , C07K2319/55 , C12N2740/16122 , C12N2740/16134 , Y02A50/472
摘要： Insertion of HIV-1 V3 loop peptides from the viral glycoprotein gp120 into selected, immunogenic scaffold proteins results in a recombinant polypeptide that is a potent V3 immunogen. V3 immunogens include natural and consensus V3 sequences and cyclic and reverse peptides. Preferred scaffold proteins are Cholera Toxin subunit B and homologues thereof including closely related E. coli enterotoxins. Such immunogenic polypeptides induce broadly reactive anti-gp120 antibodies specific for V3 epitopes that can neutralize heterologous HIV-1 subtypes and strains. These polypeptide, methods for preparing them, and methods for inducing anti-gp120 (V3-specific) antibody) responses using them are disclosed.
摘要翻译： 将HIV-1 V3环肽从病毒糖蛋白gp120插入到选定的免疫原性支架蛋白中导致重组多肽，其是有效的V3免疫原。 V3免疫原包括天然和共有的V3序列和环状和反向肽。 优选的支架蛋白是霍乱毒素亚基B及其同系物，包括密切相关的大肠杆菌肠毒素。 这样的免疫原性多肽诱导可以中和异源HIV-1亚型和菌株的V3表位特异性的广泛反应性抗gp120抗体。 公开了这些多肽，其制备方法和诱导抗gp120（V3特异性）抗体的方法）。
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