Invention Application
- Patent Title: CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS
- Patent Title (中): 周期性维生素A作为BROMODOMAIN抑制剂
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Application No.: US14914672Application Date: 2014-08-29
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Publication No.: US20160200666A1Publication Date: 2016-07-14
- Inventor: Ming-Ming ZHOU , Michael OHLMEYER , Adam VINCEK , Nilesh ZAWARE
- Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Applicant Address: US NY New York
- Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee Address: US NY New York
- International Application: PCT/US2014/053527 WO 20140829
- Main IPC: C07C225/20
- IPC: C07C225/20 ; A61K31/245 ; C07C237/30 ; A61K31/166 ; C07C229/56 ; A61K31/196 ; C07C311/38 ; A61K31/18 ; C07C255/58 ; A61K31/277 ; A61K31/136 ; C07D213/74 ; A61K31/4402 ; A61K31/4406 ; A61K31/4409 ; C07D213/75 ; C07D211/58 ; A61K31/4468 ; C07C229/48 ; C07C229/68 ; C07D241/20 ; A61K31/4965 ; C07D215/06 ; A61K31/47 ; C07D217/02 ; C07D241/42 ; A61K31/498 ; C07D239/74 ; A61K31/517 ; C07D209/08 ; A61K31/404 ; C07D235/26 ; A61K31/4184 ; C07D295/16 ; A61K31/5375 ; C07C237/40 ; C07D249/04 ; A61K31/4192 ; C07C229/60
Abstract:
Cyclic vinylogous amides of Formula I are disclosed The compounds are useful for treating diseases that arise from inappropriate activity of proteins containing an acetyl-lysine. The compositions comprise a genus of cyclic vinylogous amides that are inhibitors of bromodomain.
Public/Granted literature
- US09884806B2 Cyclic vinylogous amides as bromodomain inhibitors Public/Granted day:2018-02-06
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