Invention Application
- Patent Title: MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES
- Patent Title (中): 突变型免疫抑制蛋白结合多肽
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Application No.: US14904077Application Date: 2014-07-10
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Publication No.: US20160207966A1Publication Date: 2016-07-21
- Inventor: Mats ANDER , Goran BAUREN , Tomas BJORKMAN , Gustav RODRIGO
- Applicant: GE HEALTHCARE BIO-SCIENCES AB
- Priority: SE1350859-3 20130710; SE1350860-1 20130710
- International Application: PCT/SE2014/050882 WO 20140710
- Main IPC: C07K14/31
- IPC: C07K14/31
Abstract:
A polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A, as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamine residue at position 15 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of the polypeptide, as well as separation matrices comprising the multimers or polypeptides.
Public/Granted literature
- US09663558B2 Mutated immunoglobulin-binding polypeptides Public/Granted day:2017-05-30
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