发明申请
- 专利标题: RNA AGENTS FOR P21 GENE MODULATION
- 专利标题(中): 用于P21基因调控的RNA代理
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申请号: US14979568申请日: 2015-12-28
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公开(公告)号: US20160208255A1公开(公告)日: 2016-07-21
- 发明人: Yoshiro Niitsu , Kenjirou Minomi , Jens Harborth , Cima Cina , Kwok Yin Tsang , Wenbin Ying , Hirokazu Takahashi
- 申请人: Nitto Denko Corporation
- 优先权: JP2014-266198 20141226
- 主分类号: C12N15/113
- IPC分类号: C12N15/113
摘要:
This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. A nucleic acid molecule can have a) a polynucleotide sense strand and a polynucleotide antisense strand; b) each strand of the molecule being from 15 to 30 nucleotides in length; c) a contiguous region of from 15 to 30 nucleotides of the antisense strand being complementary to a sequence of an mRNA encoding p21; and d) at least a portion of the sense strand can be complementary to at least a portion of the antisense strand, and the molecule has a duplex region of from 15 to 30 nucleotides in length.
公开/授权文献
- US10405749B2 RNA agents for P21 gene modulation 公开/授权日:2019-09-10