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公开(公告)号:US20220233445A1
公开(公告)日:2022-07-28
申请号:US17658078
申请日:2022-04-05
发明人: Kwok Yin Tsang , Bharat Majeti , John Gaudette , Roger Adami , Hao Bai , Wenbin Ying
IPC分类号: A61K9/127 , A61K47/10 , A61K47/69 , A61K31/7105 , A61K47/14 , C07C201/00
摘要: Fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, compounds, compositions and methods are to provide nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.
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公开(公告)号:US09695206B2
公开(公告)日:2017-07-04
申请号:US14979571
申请日:2015-12-28
发明人: Kenjirou Minomi , Jens Harborth , Cima Cina , Kwok Yin Tsang , Wenbin Ying , Hirokazu Takahashi
IPC分类号: C12N15/11 , C07F9/6533 , C12N15/113 , C12Q1/02 , G01N33/58
CPC分类号: C07F9/6533 , A61K31/713 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N2310/14 , C12N2310/322 , C12N2310/344 , C12N2310/3515 , C12N2310/531 , C12N2320/30 , C12N2320/32 , C12N2320/35 , C12N2320/53 , C12Q1/02 , G01N33/582 , H05K999/99 , C12N2310/3533 , C12N2310/3531 , C12N2310/321 , C12N2310/3521
摘要: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2′-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.
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公开(公告)号:US20160208256A1
公开(公告)日:2016-07-21
申请号:US14979571
申请日:2015-12-28
发明人: Yoshiro Niitsu , Kenjirou Minomi , Jens Harborth , Cima Cina , Kwok Yin Tsang , Wenbin Ying , Hirokazu Takahashi
IPC分类号: C12N15/113
CPC分类号: C07F9/6533 , A61K31/713 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N2310/14 , C12N2310/322 , C12N2310/344 , C12N2310/3515 , C12N2310/531 , C12N2320/30 , C12N2320/32 , C12N2320/35 , C12N2320/53 , C12Q1/02 , G01N33/582 , H05K999/99 , C12N2310/3533 , C12N2310/3531 , C12N2310/321 , C12N2310/3521
摘要: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2′-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.
摘要翻译: 本发明提供了使用RNA干扰来调节人p21的表达的化合物,组合物和方法。 RNA干扰分子可用于预防或治疗恶性肿瘤等疾病的方法。 提供一系列siRNA结构,其具有一个或多个核苷酸被修饰或化学修饰。 有利的结构包括位于种子区域中具有2'-脱氧核苷酸的siRNA以及其它核苷酸修饰。
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公开(公告)号:US20190127318A1
公开(公告)日:2019-05-02
申请号:US16228054
申请日:2018-12-20
发明人: Roger Adami , Hao Bai , John Gaudette , Bharat Majeti , Seiji Nukui , Kwok Yin Tsang , Hai Wang , Haiqing Yin , Wenbin Ying
IPC分类号: C07C271/16 , A61K31/713 , C07F9/10 , C07D211/82 , C07D211/86 , C07D207/09 , C07D207/12 , C07D205/04 , C07F9/06 , C07C237/16 , C07C237/50 , C07C237/08 , A61K9/51 , A61K9/127 , A61K47/22 , A61K47/16 , A61K47/24 , A61K31/7105 , C07D211/74
摘要: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.
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公开(公告)号:US09636411B2
公开(公告)日:2017-05-02
申请号:US14786841
申请日:2013-04-26
发明人: Hao Bai , Kwok Yin Tsang , Yi Jin , Lei Yu
CPC分类号: A61K47/48207 , A61K47/645 , C08G69/10 , C08G73/028
摘要: Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-γ-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein.
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公开(公告)号:US20160208255A1
公开(公告)日:2016-07-21
申请号:US14979568
申请日:2015-12-28
发明人: Yoshiro Niitsu , Kenjirou Minomi , Jens Harborth , Cima Cina , Kwok Yin Tsang , Wenbin Ying , Hirokazu Takahashi
IPC分类号: C12N15/113
CPC分类号: A61B5/0071 , A61K31/713 , A61K49/0021 , C07D311/30 , C07F9/6533 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N2310/14 , C12N2310/322 , C12N2310/344 , C12N2310/3515 , C12N2310/531 , C12N2320/30 , C12N2320/32 , C12N2320/35 , C12N2320/53 , C12Q1/02 , G01N33/582 , H05K999/99 , C12N2310/3533 , C12N2310/3531 , C12N2310/321 , C12N2310/3521
摘要: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. A nucleic acid molecule can have a) a polynucleotide sense strand and a polynucleotide antisense strand; b) each strand of the molecule being from 15 to 30 nucleotides in length; c) a contiguous region of from 15 to 30 nucleotides of the antisense strand being complementary to a sequence of an mRNA encoding p21; and d) at least a portion of the sense strand can be complementary to at least a portion of the antisense strand, and the molecule has a duplex region of from 15 to 30 nucleotides in length.
摘要翻译: 本发明提供了使用RNA干扰来调节人p21的表达的化合物,组合物和方法。 RNA干扰分子可用于预防或治疗恶性肿瘤等疾病的方法。 核酸分子可具有a)多核苷酸有义链和多核苷酸反义链; b)分子的每条链长度为15至30个核苷酸; c)反义链的15至30个核苷酸的连续区域与编码p21的mRNA的序列互补; 和d)所述有义链的至少一部分可以与所述反义链的至少一部分互补,并且所述分子具有长度为15至30个核苷酸的双链体区。
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公开(公告)号:US20220242820A1
公开(公告)日:2022-08-04
申请号:US17658075
申请日:2022-04-05
发明人: Roger Adami , Hao Bai , John Gaudette , Bharat Majeti , Seiji Nukui , Kwok Yin Tsang , Hai Wang , Haiqing Yin , Wenbin Ying
IPC分类号: C07C271/16 , C07D205/04 , C07D207/12 , C07C237/16 , C07D207/09 , C07D211/86 , C07D211/82 , C07D211/74 , C07F9/06 , A61K31/713 , C07F9/10 , A61K31/7105 , A61K9/127 , A61K9/51 , C07C237/08 , C07C237/50 , A61K47/16 , A61K47/22 , A61K47/24
摘要: Ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, the compounds, compositions and methods are to provide nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.
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公开(公告)号:US11384051B2
公开(公告)日:2022-07-12
申请号:US16228054
申请日:2018-12-20
发明人: Roger Adami , Hao Bai , John Gaudette , Bharat Majeti , Seiji Nukui , Kwok Yin Tsang , Hai Wang , Haiqing Yin , Wenbin Ying
IPC分类号: A61K31/713 , A61K31/7105 , A61K9/127 , A61K9/51 , A61K47/16 , A61K47/22 , A61K47/24 , C07C271/16 , C07D205/04 , C07D207/12 , C07C237/16 , C07D207/09 , C07D211/86 , C07D211/82 , C07D211/74 , C07F9/06 , C07F9/10 , C07C237/08 , C07C237/50
摘要: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.
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公开(公告)号:US10167253B2
公开(公告)日:2019-01-01
申请号:US15191511
申请日:2016-06-23
发明人: Roger Adami , Hao Bai , John Gaudette , Bharat Majeti , Seiji Nukui , Kwok Yin Tsang , Hai Wang , Haiqing Yin , Wenbin Ying
IPC分类号: A61K47/16 , A61K31/17 , A61K47/18 , C07C271/16 , C07D205/04 , A61K47/22 , C07D207/12 , C07C237/16 , C07D207/09 , C07D211/86 , C07D211/82 , C07D211/74 , C07F9/06 , A61K47/24 , A61K31/713 , C07F9/10 , A61K31/7105
摘要: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.
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公开(公告)号:US10080737B2
公开(公告)日:2018-09-25
申请号:US14679404
申请日:2015-04-06
发明人: Wenbin Ying , Kwok Yin Tsang , Hao Bai , Haiqing Yin , Jihua Liu , Li Wang
IPC分类号: A61K47/48 , A61K31/337 , A61K31/395 , C08G69/48 , C08G69/10 , A61K47/64
CPC分类号: A61K31/395 , A61K31/337 , A61K47/645 , C08G69/10 , C08G69/48
摘要: Polymer conjugates characterized in that the backbone of the polymer is an anionic polymer and hydrophobic moieties are covalently attached to the polymer backbone are useful for preparing drug encapsulated polymer hydrotropes and compositions. Such materials are useful in methods for delivering the drug into cells, and for the treatment and alleviation of diseases and disorders such as cancer.
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