发明申请
US20160228419A1 SUBSTITUTED QUINOLIZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS
有权
用作艾滋病毒整合酶抑制剂的替代喹诺酮衍生物
- 专利标题： SUBSTITUTED QUINOLIZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS
- 专利标题（中）： 用作艾滋病毒整合酶抑制剂的替代喹诺酮衍生物
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申请号： US15025038申请日： 2014-09-26
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公开(公告)号： US20160228419A1公开(公告)日： 2016-08-11
- 发明人: Tao Yu , Yonglian Zhang , Sherman Tim Waddell , Andrew Stamford , John S. Wai , Paul J. Coleman , John M. Sanders , Ronald Ferguson
- 申请人： MERCK SHARP & DOHME CORP.
- 申请人地址： US NJ Rahway
- 专利权人： MERCK SHARP & DOHME CORP.
- 当前专利权人： MERCK SHARP & DOHME CORP.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US14/57572 WO 20140926
- 主分类号： A61K31/4375
- IPC分类号： A61K31/4375 ; C07D455/02 ; C07D519/00 ; C07D471/14 ; A61K31/444 ; C07D455/04 ; C07D455/00 ; A61K45/06 ; C07D491/147
摘要：
The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.