专利检索 ap:("MERCK SHARP & DOHME CORP.") AND inv:"Tao Yu" 第 1 页

1.

发明申请
TETRACYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS 有权

公开(公告)号：US20220259227A1

公开(公告)日：2022-08-18

申请号：US17670689

申请日：2022-02-14

申请人： Merck Sharp & Dohme Corp.

发明人： Timothy John Hartingh , John A. McCauley , Tao Yu , Yonglian Zhang

IPC分类号： C07D498/22 , A61K45/06

摘要： The present invention relates to Tetracyclic Heterocycle Compounds of Formula and pharmaceutically acceptable salts or prodrug thereof, wherein R1 is as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

2.

发明申请
FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS 审中-公开

公开(公告)号：US20190322666A1

公开(公告)日：2019-10-24

申请号：US16454857

申请日：2019-06-27

申请人： MERCK SHARP & DOHME CORP.

发明人： Tao Yu , Sherman T. Waddell , Thomas H. Graham , Yonglian Zhang , John A. McCauley , Andrew W. Stamford , Jiaqiang Cai , Zhiqi Qi

IPC分类号： C07D471/16 , A61K31/635 , A61K31/427 , A61K31/513 , A61K31/5365 , A61K31/4402 , A61K31/4985 , A61K31/505 , A61K31/52 , A61K31/683

摘要： The present invention relates to Fused Tricyclic Heterocyclic Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Heterocyclic Compound, and methods of using the Fused Tricyclic Heterocyclic Compounds for treating or preventing HIV infection in a subject.

3.

发明授权
Substituted quinolizine derivatives useful as HIV integrase inhibitors 有权

公开(公告)号：US10201533B2

公开(公告)日：2019-02-12

申请号：US15725407

申请日：2017-10-05

申请人： MERCK SHARP & DOHME CORP.

发明人： Tao Yu , Yonglian Zhang , Sherman Tim Waddell , John M. Sanders , Thomas H. Graham , Hong Li

IPC分类号： C07D491/00 , A61K31/44 , A61K31/4375 , C07D455/02 , A61K31/427 , A61K31/4402 , A61K31/444 , A61K31/4745 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/635 , A61K31/675 , C07D455/00 , C07D455/04 , C07D471/14 , C07D491/147 , A61K45/06 , C07D519/00

摘要： The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.

4.

发明申请
FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS 审中-公开

公开(公告)号：US20180099967A1

公开(公告)日：2018-04-12

申请号：US15840017

申请日：2017-12-13

申请人： MERCK SHARP & DOHME CORP.

发明人： Tao Yu , Sherman T. Waddell , Thomas H. Graham , Yonglian Zhang , John A. McCauley , Andrew W. Stamford , Jiaqiang Cai , Zhiqi Qi

IPC分类号： C07D471/16 , A61K31/52 , A61K31/4402 , A61K31/4985 , A61K31/505 , A61K31/427 , A61K31/5365 , A61K31/635 , A61K31/683 , A61K31/513

CPC分类号： C07D471/16 , A61K31/427 , A61K31/4402 , A61K31/4985 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/5365 , A61K31/635 , A61K31/683

摘要： The present invention relates to Fused Tricyclic Heterocyclic Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Heterocyclic Compound, and methods of using the Fused Tricyclic Heterocyclic Compounds for treating or preventing HIV infection in a subject.

5.

发明申请
PHOSPHATE SUBSTITUTED QUINOLIZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS 审中-公开

公开(公告)号：US20180051043A1

公开(公告)日：2018-02-22

申请号：US15560896

申请日：2016-03-25

申请人： Merck Sharp & Dohme Corp.

发明人： Tao Yu , Sherman T. Waddell , John A. McCauley , Thomas H. Graham , Hong Li , Izzat Raheem , Jay A. Grobler

IPC分类号： C07F9/6561 , A61K31/683 , A61K31/675

CPC分类号： C07F9/6561 , A61K31/427 , A61K31/4402 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/635 , A61K31/675 , A61K31/683 , A61K2300/00

摘要： The present invention relates to Phosphate Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Phosphate Substituted Quinolizine Derivative, and methods of using the Phosphate Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.

6.

发明授权
Piperazine-substituted [1,2,4]triazolo[1,5-C]quinazolin-5-amine compounds with A2A antagonist properties 有权

公开(公告)号：US09676780B2

公开(公告)日：2017-06-13

申请号：US14655572

申请日：2013-12-20

申请人： MERCK SHARP & DOHME CORP. , Amjad Ali , Michael Man-Chu Lo , Yeon-Hee Lim , Andrew Stamford , Rongze Kuang , Paul Tempest , Younong Yu , Michael Berlin , Pauline Ting , Gang Zhou , Tao Yu , Christopher Boyce , Joseph Michael Kelly , Jayaram R. Tagat , Junying Zheng , Xianhai Huang , Wei Zhou , Jae-Hun Kim , Nicolas Zorn , Dong Xiao , Gioconda V. Gallo , Walter Won , Heping Wu , Rajan Anand , Qiaolin Deng

发明人： Amjad Ali , Michael Man-Chu Lo , Yeon-Hee Lim , Andrew Stamford , Rongze Kuang , Paul Tempest , Younong Yu , Michael Berlin , Pauline Ting , Gang Zhou , Tao Yu , Christopher Boyce , Joseph Michael Kelly , Jayaram R. Tagat , Junying Zheng , Xianhai Huang , Wei Zhou , Jae-Hun Kim , Nicolas Zorn , Dong Xiao , Gioconda V. Gallo , Walter Won , Heping Wu , Rajan Anand , Qiaolin Deng

IPC分类号： C07D487/04 , A61K31/519 , C07D487/08 , C07D487/18 , C07D513/04

CPC分类号： C07D487/04 , C07D487/08 , C07D487/18 , C07D513/04

摘要： Disclosed are compounds of Formula A: (structurally represented) where “RG1”, “RG2a”, “RG4”, “RG5”, “MG1”, “n” and “m” are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.

7.

发明申请
TETRACYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS 审中-公开

公开(公告)号：US20190315769A1

公开(公告)日：2019-10-17

申请号：US16447271

申请日：2019-06-20

申请人： MERCK SHARP & DOHME CORP.

发明人： Thomas H. Graham , Tao Yu , Yonglian Zhang , John A. McCauley

IPC分类号： C07D498/22 , A61P31/18 , C07D498/16 , C07D487/16 , A61K31/553 , A61K31/4188 , A61K31/407 , A61K31/5365 , A61K31/4985 , C07D471/22

摘要： The present invention relates to Tetracyclic Heterocycle Compounds of Formula and pharmaceutically acceptable salts or prodrug thereof, wherein A, X, R1, R2, R3 and R7 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

8.

发明申请
Spirocyclic Pyridotriazine Derivatives Useful As HIV Integrase Inhibitors 审中-公开

公开(公告)号：US20180325926A1

公开(公告)日：2018-11-15

申请号：US15775871

申请日：2016-11-11

申请人： Merck Sharp & Dohme Corp.

发明人： Thomas H. Graham , Tao Yu , Sherman T. Waddell , John A. McCauley , Andrew Stamford , Wengsheng Liu , Jay A. Grobler , Libo Xu

IPC分类号： A61K31/675 , A61P31/18

CPC分类号： A61K31/675 , A61K31/426 , A61K31/513 , A61K31/52 , A61K2300/00 , A61P31/18 , C07D491/20 , C07F9/6561

摘要： The present invention relates to Spirocyclic Pyridotriazine Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R1, R2 and R16 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Pyridotriazine Derivative, and methods of using the Spirocyclic Pyridotriazine Derivatives for treating or preventing HIV infection in a subject.