发明申请
- 专利标题： SOFT PROTEASE INHIBITORS AND PRO-SOFT FORMS THEREOF
- 专利标题（中）： 软质蛋白酶抑制剂及其软体形式
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申请号： US14932560申请日： 2015-11-04
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公开(公告)号： US20160250237A1公开(公告)日： 2016-09-01
- 发明人: William W. Bachovchin , Hung-sen Lai , Wengen Wu
- 申请人： Trustees of Tufts College
- 主分类号： A61K31/69
- IPC分类号： A61K31/69 ; A61K38/05
摘要：
The invention provides compounds and methods for inhibiting proteases. One aspect of the invention features pro-soft inhibitors which react with an activating protease to release an active inhibitor moiety in proximity to a target protease. In certain instances, compounds inhibit proteasomes and/or post-proline cleaving enzymes (PPCE), such as dipeptidyl peptidase IV. The compounds of the invention provide a better therapeutic index, owing in part to reduced toxicity and/or improved specificity for the targeted protease.
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