公开(公告)号：US20230081694A1

公开(公告)日：2023-03-16

申请号：US17796221

申请日：2021-01-29

申请人： Trustees of Tufts College

发明人： Charles R. Mace ,  Keith Baillargeon ,  Jessica C. Brooks

IPC分类号： G01N33/49 ,  B01D63/08 ,  G01N33/50 ,  G01N1/40 ,  B01L3/00

摘要： Disclosed herein are articles and methods for blood separation. For example, inventive articles and methods that remove red blood cells from blood samples are described.

公开(公告)号：US11576862B2

公开(公告)日：2023-02-14

申请号：US15646601

申请日：2017-07-11

申请人： Trustees of Tufts College

发明人： David L. Kaplan ,  Tuna Yucel ,  Xiaoqin Wang ,  Michael Lovett

IPC分类号： A61K9/16 ,  A61K9/00 ,  A61K31/13 ,  C07K16/22 ,  A61K47/38

摘要： Provided herein relates to methods and compositions for preparing a silk microsphere and the resulting silk microsphere. In some embodiments, the methods and compositions described herein are all aqueous, which can be used for encapsulating an active agent in a silk microsphere, while maintaining activity of the active agent during processing. In some embodiments, the resulting silk microsphere can be used for sustained delivery of an active agent encapsulated therein.

公开(公告)号：US20220370647A1

公开(公告)日：2022-11-24

申请号：US17211481

申请日：2021-03-24

申请人： Trustees of Tufts College

发明人： William W. Bachovchin ,  Hung-sen Lai ,  Wengen Wu

IPC分类号： A61K51/04

摘要： The tumor stroma, which accounts for a large part of the tumor mass, represents an attractive target for the delivery of diagnostic and therapeutic compounds. Here, the focus is notably on a subpopulation of stromal cells, known as cancer-associated fibroblasts, which are present in more than 90% of epithelial carcinomas, including pancreatic, colon, and breast cancer. Cancer-associated fibroblasts feature high expression of FAP, which is not detectable in adult normal tissue but is associated with a poor prognosis in cancer patients. The present invention provides small-molecule radiopharmaceutical and imaging agents based on a FAP-specific inhibitor.

公开(公告)号：US20220306922A1

公开(公告)日：2022-09-29

申请号：US17596896

申请日：2020-06-19

申请人： Trustees of Tufts College ,  University of Bari Aldo Moro

发明人： Fiorenzo G. Omenetto ,  Gianluca M. Farinola ,  Marco Lo Presti

IPC分类号： C09J189/00

摘要： An adhesive composition and methods of making and using the same are disclosed. The composition includes a polymeric component and a metal cation or an oxidant. The polymeric component includes a silk fibroin protein and a catecholamine. The metal cation and/or the oxidant is present in an amount sufficient to initiate complexing and/or cross-linking of the adhesive composition.

公开(公告)号：US20220299494A1

公开(公告)日：2022-09-22

申请号：US17753312

申请日：2020-08-28

申请人： Trustees of Tufts College

发明人： David L. Kaplan ,  Qiaobing Xu

IPC分类号： G01N33/15 ,  C12N5/071 ,  A61K9/51 ,  G01N33/50

摘要： The present disclosure provides a method for screening drug delivery vehicles for use in delivering cargo via oral delivery. The method includes introducing a drug delivery vehicle comprising an imaging agent into a lumen of an artificial intestine system composed of a scaffold matrix material. The scaffold matrix material includes an interconnected network of pores, intestinal epithelial cells positioned on an inner surface of the lumen, and human-based cells positioned within the pores and surrounding the intestinal epithelial cells. The method includes maintaining the artificial intestine system in physiologically relevant conditions for a predetermined length of time, and detecting a color change induced by the imaging agent within at least a portion of the human-based cells.

公开(公告)号：US11447753B2

公开(公告)日：2022-09-20

申请号：US16868243

申请日：2020-05-06

申请人： Northwestern University ,  Board of Regents of the University of Nebraska ,  Trustees of Tufts College (AKA Tufts University)

发明人： Gregory A. Smith ,  Patricia Jane Sollars ,  Gary Edward Pickard ,  Ekaterina E. Heldwein

IPC分类号： A61K39/245 ,  A61K39/25 ,  C12N7/00 ,  C07K14/005 ,  A61K39/12 ,  A61K35/763 ,  A61K39/00

摘要： Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.

公开(公告)号：US20220283113A1

公开(公告)日：2022-09-08

申请号：US17545151

申请日：2021-12-08

申请人： Trustees of Tufts College ,  DTAMedical

发明人： Sameer Sonkusale ,  Junfei Xia ,  Francois Dufay

IPC分类号： G01N27/409 ,  G01N27/406 ,  G01N27/407

摘要： An oxygen sensor for sensing dissolved oxygen concentration in tissue includes an electrochemical sensor comprising first and second conductive threads having proximal sections connected to a potentiostat. The first thread forms a cathode, and the second thread forms an anode.

公开(公告)号：US20220218267A1

公开(公告)日：2022-07-14

申请号：US17617654

申请日：2020-06-12

申请人： Trustees of Tufts College

发明人： Sergio Fantini ,  Angelo Sassaroli ,  Giles Blaney

IPC分类号： A61B5/00 ,  H01J49/40 ,  A61N5/06 ,  A61B5/026

摘要： An apparatus for earning out near-infrared spectroscopy using intensity-modulated near-infrared radiation or pulsed near-infrared radiation includes sources and detectors. For each source, there exists first and second distances. The first distance is a distance between the source and a first detector. The second distance is a distance between the source and the second detector. For each source, the difference between these two distances is the same. Additionally, wherein, for each source, the detector at a shorter distance is the same detector that is at a longer distance for the other source. A processor derives, from signals received by the detectors, a parameter indicative of two matched slopes. Tins parameter is either phase of the intensity-modulated near-infrared radiation or mean time-of-flight data for the pulsed near-infrared radiation. The processor then provides output data based on an average of the matched slopes. This promotes reduced sensitivity to superficial layers and enhanced sensitivity to deeper portions of a medium that is under investigation.

公开(公告)号：US11386507B2

公开(公告)日：2022-07-12

申请号：US16579454

申请日：2019-09-23

申请人： International Business Machines Corporation ,  TRUSTEES OF TUFTS COLLEGE ,  Ramot at Tel-Aviv University Ltd.

发明人： Lior Horesh ,  Osman Asif Malik ,  Shashanka Ubaru ,  Misha E. Kilmer ,  Haim Avron

IPC分类号： G06Q50/00 ,  G06F17/16 ,  G06N20/00 ,  G06F16/901

摘要： A computer-implemented method for analyzing a time-varying graph is provided. The time-varying graph includes nodes representing elements in a network, edges representing transactions between elements, and data associated with the nodes and the edges. The computer-implemented method includes constructing, using a processor, adjacency and feature matrices describing each node and edge of each time-varying graph for stacking into an adjacency tensor and describing the data of each time-varying graph for stacking into a feature tensor, respectively. The adjacency and feature tensors are partitioned into adjacency and feature training tensors and into adjacency and feature validation tensors, respectively. An embedding model and a prediction model are created using the adjacency and feature training tensors. The embedding and prediction models are validated using the adjacency and feature validation tensors to identify an optimized embedding-prediction model pair.

公开(公告)号：US20220211883A1

公开(公告)日：2022-07-07

申请号：US17554823

申请日：2021-12-17

申请人： Trustees of Tufts College

发明人： William W. Bachovchin ,  Hung-sen Lai ,  Wengen Wu

IPC分类号： A61K51/04

摘要： The present disclosure relates to fibroblast-activation protein (FAP)-activated theranostic prodrugs, pharmaceutical compositions comprising them, and methods of treating a disorder characterized by FAP upregulation, such as cancer.