- 专利标题： TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
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申请号： US15153692申请日： 2016-05-12
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公开(公告)号： US20160257692A1公开(公告)日： 2016-09-08
- 发明人: Kenneth W. BAIR , Torsten HERBERTZ , Goss S. KAUFFMAN , Katherine J. KAYSER-BRICKER , George P. LUKE , Matthew W. MARTIN , David S. MILLAN , Shawn E.R. SCHILLER , Adam C. TALBOT
- 申请人： Forma Therapeutics, Inc.
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/4709 ; A61K45/06 ; C07D401/12 ; A61K31/5377 ; C07D417/14 ; C07D405/14 ; C07D409/14 ; A61K31/517 ; C07D413/14 ; A61K31/506 ; A61K31/519 ; A61K31/497 ; A61K31/501 ; C07D413/04 ; C07D471/04 ; C07D417/04 ; C07D473/28 ; A61K31/52 ; A61K31/496 ; C07D215/20 ; A61K31/47 ; C07D417/10 ; C07D405/04 ; C07D401/04
摘要：
The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein.
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