Invention Application
US20160280692A1 N-(MONOCYCLIC ARYL),N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
有权
作为TRKA激酶抑制剂的N-(单环芳烃),N'-吡唑并 - 尿酸,硫脲,胍和氰基胍化合物
- Patent Title: N-(MONOCYCLIC ARYL),N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
- Patent Title (中): 作为TRKA激酶抑制剂的N-(单环芳烃),N'-吡唑并 - 尿酸,硫脲,胍和氰基胍化合物
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Application No.: US14442604Application Date: 2013-11-12
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Publication No.: US20160280692A1Publication Date: 2016-09-29
- Inventor: Steven Wade Andrews , James F. Blake , Barbara J. Brandhuber , Timothy Kercher , Shannon L. Winski
- Applicant: ARRAY BIOPHARMA INC.
- Applicant Address: US CO Boulder
- Assignee: ARRAY BIOPHARMA INC.
- Current Assignee: ARRAY BIOPHARMA INC.
- Current Assignee Address: US CO Boulder
- International Application: PCT/US2013/069732 WO 20131112
- Main IPC: C07D405/12
- IPC: C07D405/12 ; C07D231/40 ; C07D231/52 ; C07D405/04 ; C07D401/12 ; C07D401/14 ; C07D401/04

Abstract:
Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
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