Invention Application
US20160304505A1 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE
有权
2-氨基甲酰乙酰和亚磺酰氨基苯甲酰胺碳酸酯抑制罗尔玛活性和治疗疾病
- Patent Title: 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE
- Patent Title (中): 2-氨基甲酰乙酰和亚磺酰氨基苯甲酰胺碳酸酯抑制罗尔玛活性和治疗疾病
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Application No.: US15103407Application Date: 2014-12-19
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Publication No.: US20160304505A1Publication Date: 2016-10-20
- Inventor: Thomas D. Aicher , Chad A. VanHuis , John MacLean , Brian M. Andresen , Kenneth J. Barr , Corey Bienstock , Neville J. Anthony , Matthew Daniels , Yuan Liu , Catherine White , Blair T. Lapointe , Nunzio Sciammetta , Vladimir Simov , Wesley B. Trotter , Kun Liu
- Applicant: MERCK SHARP & DOHME CORP. , LYCERA CORPORATION
- International Application: PCT/US14/71656 WO 20141219
- Main IPC: C07D413/12
- IPC: C07D413/12 ; A61K31/538 ; C07D265/36 ; C07D413/14 ; C07D498/04 ; C07D513/04 ; C07D487/04 ; C07D417/12 ; A61K45/06 ; C07D471/04
Abstract:
The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, Ra, Rb, Rc, Rd, Rg, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.
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