Disclosed is a user interface which enables mark based interaction for images. The present disclosure relates to a user interface which enables mark based interaction for images, the images comprising a volume which is a three-dimensional image and slices which are two-dimensional images, each of which represents a cross section of the volume. At least two of the images each include the same visual mark for identifying at least one common region of interest. The user interface comprises: an input unit for receiving a user input associated with the same visual mark included in one of the images; and at least one component for enabling the interaction for the images including the same visual mark associated with the user input.