发明申请
- 专利标题: INTRAPULMONARY ADMINISTRATION OF POLYNUCLEOTIDE TOLL-LIKE RECEPTOR 9 AGONISTS FOR TREATING CANCER OF THE LUNG
- 专利标题(中): 多核胆固醇受体诱导治疗肺癌癌症的药物治疗
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申请号: US15162535申请日: 2016-05-23
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公开(公告)号: US20160346312A1公开(公告)日: 2016-12-01
- 发明人: Cristiana GUIDUCCI , Robert L. COFFMAN
- 申请人: Dynavax Technologies Corporation
- 主分类号: A61K31/713
- IPC分类号: A61K31/713 ; A61K9/00 ; A61K45/06
摘要:
The present disclosure relates to methods for treating cancer by intrapulmonary administration of a polynucleotide Toll-like receptor 9 agonist. The methods of the present disclosure are suitable for treating primary cancer of the lung, as well as metastatic cancer to the lung and extra pulmonary cancers thereof. Additionally, the present disclosure provides polynucleotide Toll-like receptor 9 agonists with immune stimulatory and toxicity profiles suitable for intrapulmonary administration.
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