公开(公告)号：US20190240323A1

公开(公告)日：2019-08-08

申请号：US15958295

申请日：2018-04-20

申请人： Dynavax Technologies Corporation

发明人： Gary S. OTT ,  Robert J. MILLEY ,  Robert L. COFFMAN ,  Radwan KIWAN ,  Holger KANZLER

IPC分类号： A61K39/39 ,  A61K47/61 ,  C07H21/00 ,  A61K47/60 ,  A61K39/12 ,  C07H21/04 ,  A61K31/7125 ,  A61K39/07

CPC分类号： A61K39/39 ,  A61K31/7125 ,  A61K39/07 ,  A61K39/12 ,  A61K47/60 ,  A61K47/61 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55561 ,  A61K2039/572 ,  A61K2039/575 ,  C07H21/00 ,  C07H21/04 ,  C12N2730/10134

摘要： The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.

公开(公告)号：US20190151462A1

公开(公告)日：2019-05-23

申请号：US16190010

申请日：2018-11-13

申请人： Dynavax Technologies Corporation

发明人： Robert L. COFFMAN ,  Stewart D. CHIPMAN ,  Radwan KIWAN ,  Samuel ZALIPSKY ,  Gary S. OTT

IPC分类号： A61K47/65 ,  A61K47/68 ,  A61P35/00 ,  A61K47/60 ,  A61K31/4745

摘要： The present disclosure relates to cleavable conjugates (for example, particle-based or antibody-based conjugates) of TLR7/8 agonists (for example, 1H-imidazo[4,5-c]quinoline derivatives) containing a conjugation linker, a cleavable linker, and a self-eliminating linker. The present disclosure also related to methods for preparation of the cleavable conjugates, uses thereof for stimulating an effective immune response, and uses thereof for the treatment of cancer.

公开(公告)号：US20160346312A1

公开(公告)日：2016-12-01

申请号：US15162535

申请日：2016-05-23

申请人： Dynavax Technologies Corporation

发明人： Cristiana GUIDUCCI ,  Robert L. COFFMAN

IPC分类号： A61K31/713 ,  A61K9/00 ,  A61K45/06

CPC分类号： A61K31/713 ,  A61K9/0073 ,  A61K31/7125 ,  A61K45/06

摘要： The present disclosure relates to methods for treating cancer by intrapulmonary administration of a polynucleotide Toll-like receptor 9 agonist. The methods of the present disclosure are suitable for treating primary cancer of the lung, as well as metastatic cancer to the lung and extra pulmonary cancers thereof. Additionally, the present disclosure provides polynucleotide Toll-like receptor 9 agonists with immune stimulatory and toxicity profiles suitable for intrapulmonary administration.

摘要翻译： 本公开涉及通过肺内施用多核苷酸Toll样受体9激动剂治疗癌症的方法。 本公开的方法适用于治疗肺的原发性癌症，以及肺转移性癌症及其额外的肺癌。 另外，本公开提供具有适于肺内给药的免疫刺激和毒性特征的多核苷酸Toll样受体9激动剂。

公开(公告)号：US20180360954A1

公开(公告)日：2018-12-20

申请号：US15958292

申请日：2018-04-20

申请人： Dynavax Technologies Corporation

发明人： Gary S. OTT ,  Robert J. MILLEY ,  Robert L. COFFMAN ,  Radwan KIWAN ,  Holger KANZLER

IPC分类号： A61K39/39 ,  A61K31/7125

CPC分类号： A61K39/39 ,  A61K31/7125 ,  A61K39/07 ,  A61K39/12 ,  A61K47/60 ,  A61K47/61 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55561 ,  A61K2039/572 ,  A61K2039/575 ,  C07H21/00 ,  C07H21/04 ,  C12N2730/10134

摘要： The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.

公开(公告)号：US20160003807A1

公开(公告)日：2016-01-07

申请号：US14694919

申请日：2015-04-23

申请人： Dynavax Technologies Corporation

发明人： Franck BARRAT ,  Robert L. COFFMAN ,  Cristiana GUIDUCCI

IPC分类号： G01N33/50 ,  C07K14/705 ,  C12N5/0789

CPC分类号： G01N33/5073 ,  A01K67/0271 ,  A01K67/0278 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0387 ,  C07K14/705 ,  C07K14/70596 ,  C12N5/0647 ,  C12N2510/00 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/5038

摘要： Provided herein are human Toll-like receptor 8 (TLR8)-expressing transgenic animals and methods of use thereof.

摘要翻译： 本文提供了表达转基因动物的人Toll样受体8（TLR8）及其使用方法。

公开(公告)号：US20210196819A1

公开(公告)日：2021-07-01

申请号：US17000149

申请日：2020-08-21

申请人： MERCK SHARP & DOHME CORP. ,  DYNAVAX TECHNOLOGIES CORPORATION

发明人： Ying YU ,  Andrew Evan DENKER ,  Svetlana SADEKOVA ,  Uyen Truong PHAN ,  Robert A. KASTELEIN ,  David Ross KAUFMAN ,  Robert L. COFFMAN ,  Cristiana GUIDUCCI ,  Robert S. JANSSEN

IPC分类号： A61K39/395 ,  A61K45/06 ,  A61K31/7115 ,  C07K14/435 ,  A61K39/39 ,  C07K16/28 ,  C07K16/24 ,  A61P35/00

摘要： The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a Toll-like receptor 9 (T1119) agonist that is a CpG-C type oligonucleotide, and the use of the combination therapies for the treatment of cancer.

公开(公告)号：US20180264023A1

公开(公告)日：2018-09-20

申请号：US15989055

申请日：2018-05-24

申请人： Dynavax Technologies Corporation

发明人： Cristiana GUIDUCCI ,  Robert L. COFFMAN

IPC分类号： A61K31/713 ,  A61K31/7125 ,  A61K9/00 ,  A61K45/06

CPC分类号： A61K31/713 ,  A61K9/0073 ,  A61K31/7125 ,  A61K45/06

摘要： The present disclosure relates to methods for treating cancer by intrapulmonary administration of a polynucleotide Toll-like receptor 9 agonist. The methods of the present disclosure are suitable for treating primary cancer of the lung, as well as metastatic cancer to the lung and extra pulmonary cancers thereof. Additionally, the present disclosure provides polynucleotide Toll-like receptor 9 agonists with immune stimulatory and toxicity profiles suitable for intrapulmonary administration.

公开(公告)号：US20180169229A1

公开(公告)日：2018-06-21

申请号：US15577369

申请日：2016-05-26

申请人： Ying YU ,  Andrew Evan DENKER ,  Svetlana SADEKOVA ,  Uyen truong PHAN ,  Robert A. KASTELEIN ,  David Ross KAUFMAN ,  Robert L. COFFMAN ,  Cristiana GUIDUCCI ,  Robert S. JANSSEN ,  MERCK SHARP & DOHME CORP. ,  DYNAVAX TECHNOLOGIES CORPORATION

发明人： Ying YU ,  Andrew Evan DENKER ,  Svetlana SADEKOVA ,  Uyen Truong PHAN ,  Robert A. KASTELEIN ,  David Ross KAUFMAN ,  Robert L. COFFMAN ,  Cristiana GUIDUCCI ,  Robert S. JANSSEN

IPC分类号： A61K39/395 ,  A61K31/7115 ,  A61K45/06 ,  C07K14/435 ,  A61P35/00

摘要： The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a Toll-like receptor 9 (TLR9) agonist that is a CpG-C type oligonucleotide, and the use of the combination therapies for the treatment of cancer.

公开(公告)号：US20150050296A1

公开(公告)日：2015-02-19

申请号：US14312533

申请日：2014-06-23

申请人： Dynavax Technologies Corporation

发明人： Franck BARRAT ,  Robert L. COFFMAN

IPC分类号： C07K14/705

CPC分类号： C07K14/705 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/318 ,  C12N2310/3183 ,  C12N2310/336

摘要： The invention provides immunoregulatory polynucleotides and methods for immunoregulation of individuals using the immunoregulatory polynucleotides.

摘要翻译： 本发明提供免疫调节多核苷酸和使用免疫调节多核苷酸免疫调节个体的方法。

公开(公告)号：US20230072809A1

公开(公告)日：2023-03-09

申请号：US17910332

申请日：2021-03-09

申请人： Dynavax Technologies Corporation ,  Serum Institute of India Private Limited

发明人： John D. CAMPBELL ,  Robert L. COFFMAN ,  Randall N. HYER ,  Robert S. JANSSEN ,  David NOVACK ,  Martin GOHLKE ,  Maureen URBAN ,  Sunil GAIROLA ,  Umesh SHALLIGRAM ,  Manish GAUTUM ,  Harish RAO

IPC分类号： A61K39/02 ,  A61K39/08 ,  A61K39/05 ,  A61K39/13 ,  A61P31/04

摘要： The present disclosure relates to immunogenic compositions comprising tetanus, diphtheria, and acellular pertussis (Tdap) antigens, and a toll-like receptor 9 (TLR9) agonist, such as oligonucleotide comprising an unmethylated cytidine-phospho-guanosine (CpG) motif. The immunogenic compositions may further comprise an aluminum salt adjuvant to which the Tdap antigens are adsorbed. The immunogenic compositions are suitable for active booster immunization against tetanus, diphtheria, and pertussis in an individual in need thereof.